Reactome | CTSL3 [lysosomal lumen]

CTSL3 [lysosomal lumen]

Stable Identifier

R-CFA-1181225

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

lysosomal lumen

Synonyms

CTSL1(114-288), A0A8I3MS69

Locations in the PathwayBrowser

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Cell-Cell communication (Canis familiaris)

- Cell junction organization (Canis familiaris)
  - Cell-cell junction organization (Canis familiaris)
    - Adherens junctions interactions (Canis familiaris)
      - Activation of STAT3 by cadherin engagement (Canis familiaris)
        
        SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) (Canis familiaris)
        
        Lysosomal degradation of ubiquitinated CDH1 (Canis familiaris)
        
        (CTSB,CTSL,CTSS) [lysosomal lumen] (Canis familiaris)
        
        CTSL [lysosomal lumen] (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)
        
        CTSL [lysosomal lumen] (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)
      - Regulation of Homotypic Cell-Cell Adhesion (Canis familiaris)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Canis familiaris)
        
        Regulation of CDH1 Expression and Function (Canis familiaris)
        
        Regulation of CDH1 Function (Canis familiaris)
        
        Degradation of CDH1 (Canis familiaris)
        
        Lysosomal degradation of ubiquitinated CDH1 (Canis familiaris)
        
        (CTSB,CTSL,CTSS) [lysosomal lumen] (Canis familiaris)
        
        CTSL [lysosomal lumen] (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)
        
        CTSL [lysosomal lumen] (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional regulation by RUNX1 (Canis familiaris)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Canis familiaris)
        
        SERPINB13 binds cathepsin L (Canis familiaris)
        
        Cathepsin L [lysosomal lumen] (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)
        
        SERPINB13:cathepsin L [lysosomal lumen] (Canis familiaris)
        
        Cathepsin L [lysosomal lumen] (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)

Metabolism (Canis familiaris)

- Metabolism of carbohydrates and carbohydrate derivatives (Canis familiaris)
  - Glycosaminoglycan metabolism (Canis familiaris)
    - Heparan sulfate/heparin (HS-GAG) metabolism (Canis familiaris)
      - HS-GAG degradation (Canis familiaris)
        
        CTSL1 cleaves proHPSE (Canis familiaris)
        
        CTSL3 [lysosomal lumen] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MS69

Gene Names

CTSL3

Reference Genes

ENSEMBL:ENSCAFG00845005046.1

UCSC:A0A8I3MS69 CTSL3

Other Identifiers

484140

CfaAffx.2856.1.S1_at

CfaAffx.2856.1.S1_s_at

GO:0005576

GO:0006508

GO:0008233

GO:0008234

GO:0016324

GO:0016787

GO:0031410

GO:0042583

Participates

as a candidate of

Cathepsin [lysosomal lumen] (Canis familiaris)

as a member of

as a component of

CTSL [lysosomal lumen] (Canis familiaris)

Other forms of this molecule

CTSL3 [extracellular region]

CTSL3 [lysosomal lumen]

CTSL3 [endolysosome lumen]

Inferred From

CTSL1(114-288) [lysosomal lumen] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845007126, ENSCAFT00845009040, ENSCAFG00845005046