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sem-5 [cytosol]
Stable Identifier
R-CEL-74686
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
GRB2-1, P29355
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
NCAM signaling for neurite out-growth (Caenorhabditis elegans)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
pFAK:Grb2:Sos [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
pFAK:Grb2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
pFAK:Grb2:Sos [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
pFAK:Grb2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
FLT3 Signaling (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)
Active FLT3:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Active FLT3: GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Caenorhabditis elegans)
Regulation of signaling by CBL (Caenorhabditis elegans)
CBL ubiquitinates PI3K (Caenorhabditis elegans)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1:PIK3R1 [cytosol] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1:PIK3R1 [cytosol] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1:PIK3R1 [cytosol] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1:PIK3R1 [cytosol] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
RAS GEFs [plasma membrane] (Caenorhabditis elegans)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Active FLT3:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Active FLT3: GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
pFAK:Grb2:Sos [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
Gastrin-CREB signalling pathway via PKC and MAPK (Caenorhabditis elegans)
EGFR Transactivation by Gastrin (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CBL binds to GRB2 (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2 events in EGFR signaling (Caenorhabditis elegans)
GRB2-1 binds SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SHC1 events in EGFR signaling (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
GRB2 events in ERBB2 signaling (Caenorhabditis elegans)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
FRS-mediated FGFR1 signaling (Caenorhabditis elegans)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1:PIK3R1 [cytosol] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR1 (Caenorhabditis elegans)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
FRS-mediated FGFR2 signaling (Caenorhabditis elegans)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR2 (Caenorhabditis elegans)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
FRS-mediated FGFR3 signaling (Caenorhabditis elegans)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR3 (Caenorhabditis elegans)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
FRS-mediated FGFR4 signaling (Caenorhabditis elegans)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1:PIK3R1 [cytosol] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR4 (Caenorhabditis elegans)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
GRB2-1 binds SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
MET phosphorylates GAB1 (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
MET activates RAS signaling (Caenorhabditis elegans)
Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
MET promotes cell motility (Caenorhabditis elegans)
MET activates RAP1 and RAC1 (Caenorhabditis elegans)
CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
DOCK7 activates RAC1 (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RAPGEF1 activates RAP1 (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
MET receptor recycling (Caenorhabditis elegans)
GGA3 associates with activated MET receptor (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
CBL binds MET (Caenorhabditis elegans)
CBL:GRB2,CBL [cytosol] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CBL monoubiquitinates activated MET (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
MET phosphorylates CBL (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by SCF-KIT (Caenorhabditis elegans)
Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Regulation of KIT signaling (Caenorhabditis elegans)
Recruitment of CBL to KIT (Caenorhabditis elegans)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RHOU GTPase cycle (Caenorhabditis elegans)
RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOU effectors [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RHOU:GTP:RHOU effectors [plasma membrane] (Caenorhabditis elegans)
RHOU effectors [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
sem-5 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P29355
Gene Names
sem-5
Reference Genes
BioGPS Gene:181055 sem-5
CTD Gene:181055 sem-5
ENSEMBL:WBGene00004774
KEGG:cel:CELE_C14F5.5 sem-5
Monarch:181055 sem-5
NCBI Gene:181055 sem-5
UCSC:P29355 sem-5
Wormbase:WBGene00004774
Wormbase:WBGene00004774 sem-5
Reference Transcript
RefSeq:NM_076941.5 sem-5
Other Identifiers
181055
18619882
187892_at
A_12_P118939
C14F5.5
C14F5.5_437-496_0.941_8_C
C14F5.5_496-555_0.941_6_B
C14F5.5_620-679_0.964_1_A
C14F5_5P00008
C14F5_5P00418
C14F5_5P00581
CE01784
CE_WBGene00004774_A
CGZ0004660
GO:0001784
GO:0005154
GO:0005515
GO:0005654
GO:0005737
GO:0005886
GO:0007165
GO:0007173
GO:0007517
GO:0008180
GO:0022414
GO:0030334
GO:0030539
GO:0031344
GO:0040028
GO:0043408
GO:0048856
GO:0061062
WBGene00004774
cea2.c.41317
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Caenorhabditis elegans)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Caenorhabditis elegans)
p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
CBL:GRB2 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
pFAK:Grb2 [cytosol] (Caenorhabditis elegans)
pFAK:Grb2:Sos [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
Active FLT3: GRB2 [plasma membrane] (Caenorhabditis elegans)
GRB2:GAB1 [cytosol] (Caenorhabditis elegans)
as a member of
RHOU effectors [cytosol] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
as an input of
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)
CBL binds to GRB2 (Caenorhabditis elegans)
Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)
GRB2-1 binds SOS1 (Caenorhabditis elegans)
Inferred From
GRB2-1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_509342.1
ENSEMBL
WBGene00004774
,
C14F5.5.1
,
C14F5.5.1
PRO
P29355
PDB
1SEM
,
1K76
,
2SEM
,
3SEM
,
1KFZ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-7139453 PP-G4-L
0.558
2
IntAct:EBI-7139534 L
0.558
2
UniProt:Q62245 Sos1
4
phospho-Sos1 [cytosol]
(R-MMU-109821)
Sos1 [cytosol]
(R-MMU-443318)
Sos1 [plasma membrane]
(R-MMU-983559)
Sos1 [cytosol]
(R-MMU-64847)
0.558
2
UniProt:Q9N5D3
2
sos-1 [cytosol]
(R-CEL-167221)
sos-1 [cytosol]
(R-CEL-64847)
0.553
2
UniProt:Q9TYS3
8
FTL [extracellular region]
(R-CEL-2187214-2)
FTL [azurophil granule lumen]
(R-CEL-6799149-2)
FTH1 [tertiary granule lumen]
(R-CEL-6801508-2)
FTH1 [extracellular region]
(R-CEL-2187212-2)
FTH1 [ficolin-1-rich granule lumen]
(R-CEL-6801531-2)
FTMT [mitochondrial matrix]
(R-CEL-5691095-2)
FTH1 [cytosol]
(R-CEL-434212-2)
FTL [cytosol]
(R-CEL-434215-2)
0.553
2
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