Reactome | sem-5 [cytosol]

sem-5 [cytosol]

Stable Identifier

R-CEL-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

GRB2-1, P29355

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - FLT3 Signaling (Caenorhabditis elegans)
    - SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)
      - Active FLT3:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        Active FLT3: GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Caenorhabditis elegans)
      - Regulation of signaling by CBL (Caenorhabditis elegans)
        
        CBL ubiquitinates PI3K (Caenorhabditis elegans)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
    - Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        SH3 domain proteins [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        SH3 domain proteins [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        SH3 domain proteins [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        SH3 domain proteins [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        SH3 domain proteins [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        SH3 domain proteins [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y371-CBL:GRB2 [cytosol] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P29355

Gene Names

sem-5

Reference Genes

BioGPS Gene:181055 sem-5

CTD Gene:181055 sem-5

ENSEMBL:WBGene00004774

KEGG:cel:CELE_C14F5.5 sem-5

Monarch:181055 sem-5

NCBI Gene:181055 sem-5

UCSC:P29355 sem-5

Wormbase:WBGene00004774

Wormbase:WBGene00004774 sem-5

Reference Transcript

RefSeq:NM_076941.5 sem-5

Other Identifiers

181055

18619882

187892_at

A_12_P118939

C14F5.5

C14F5.5_437-496_0.941_8_C

C14F5.5_496-555_0.941_6_B

C14F5.5_620-679_0.964_1_A

C14F5_5P00008

C14F5_5P00418

C14F5_5P00581

CE01784

CE_WBGene00004774_A

CGZ0004660

GO:0001784

GO:0005154

GO:0005515

GO:0005654

GO:0005737

GO:0005886

GO:0007165

GO:0007173

GO:0007517

GO:0008180

GO:0022414

GO:0030334

GO:0030539

GO:0031344

GO:0040028

GO:0043408

GO:0048856

GO:0061062

WBGene00004774

cea2.c.41317

Participates

as a component of

as a member of

as an input of

Inferred From

GRB2-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_509342.1

ENSEMBL

WBGene00004774, C14F5.5.1, C14F5.5.1

PRO

P29355

PDB

1SEM, 1K76, 2SEM, 3SEM, 1KFZ

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-7139453 PP-G4-L			0.558	2
IntAct:EBI-7139534 L			0.558	2
UniProt:Q62245 Sos1	4	phospho-Sos1 [cytosol] (R-MMU-109821) Sos1 [cytosol] (R-MMU-443318) Sos1 [plasma membrane] (R-MMU-983559) Sos1 [cytosol] (R-MMU-64847)	0.558	2
UniProt:Q9N5D3	2	sos-1 [cytosol] (R-CEL-167221) sos-1 [cytosol] (R-CEL-64847)	0.553	2
UniProt:Q9TYS3	8	FTL [extracellular region] (R-CEL-2187214-2) FTL [azurophil granule lumen] (R-CEL-6799149-2) FTH1 [tertiary granule lumen] (R-CEL-6801508-2) FTH1 [extracellular region] (R-CEL-2187212-2) FTH1 [ficolin-1-rich granule lumen] (R-CEL-6801531-2) FTMT [mitochondrial matrix] (R-CEL-5691095-2) FTH1 [cytosol] (R-CEL-434212-2) FTL [cytosol] (R-CEL-434215-2)	0.553	2

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