Reactome | sos-1 [cytosol]

sos-1 [cytosol]

Stable Identifier

R-CEL-64847

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

SOS1, Q9N5D3

Locations in the PathwayBrowser

Expand all

Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - FLT3 Signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
        
        RAS GEFs [plasma membrane] (Caenorhabditis elegans)
        
        Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        pFAK:Grb2:Sos [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)
        
        SOS-1 bound to Tie2:Grb2 [plasma membrane] (Caenorhabditis elegans)
        
        sos-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9N5D3

Gene Names

sos-1

Reference Genes

BioGPS Gene:178846 sos-1

CTD Gene:178846 sos-1

ENSEMBL:WBGene00004947

KEGG Gene (Caenorhabditis elegans):CELE_T28F12.3 sos-1

Monarch:178846 sos-1

NCBI Gene:178846 sos-1

UCSC:Q9N5D3 sos-1

Wormbase:WBGene00004947

Reference Transcript

RefSeq:NM_071834.4 sos-1

Other Identifiers

177179_at

178846

184768_at

18597466

A_12_P117529

CE28779

CE_WBGene00004947_A

CGZ0037524

GO:0000003

GO:0003674

GO:0005085

GO:0005088

GO:0005516

GO:0007165

GO:0007264

GO:0007292

GO:0008150

GO:0009790

GO:0009792

GO:0016477

GO:0019899

GO:0040011

GO:0040026

GO:0046982

GO:0048856

GO:0048870

T28F12.3

T28F12.3_1166-1225_0.793_96_B

T28F12.3_2003-2062_0.809_70_A

T28F12.3_3327-3386_0.847_33_C

T28F12_3P03166

T28F12_3P03655

T28F12_3P03990

WBGene00004947

cea2.p.126210

Participant Of

hasMember

GEFs [cytosol]

input

hasComponent

Other forms of this molecule

sos-1 [cytosol]

Inferred From

SOS1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_504235.2

PRO

Q9N5D3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29355	2	sem-5 [cytosol] (R-CEL-74686) sem-5 [plasma membrane] (R-CEL-202993)	0.553	2

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