Reactome | hrpa-1 [nucleoplasm]

hrpa-1 [nucleoplasm]

Stable Identifier

R-CEL-71927

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

HNRNPA1, Q22037

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
  - Formation of pre-mRNPs (Caenorhabditis elegans)
    - Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
      - shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
      - Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
  - mRNA 3'-end processing (Caenorhabditis elegans)
    - mRNA Polyadenylation (Caenorhabditis elegans)
      - Core CPA complex binds capped pre-mRNA (Caenorhabditis elegans)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Caenorhabditis elegans)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Caenorhabditis elegans)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Caenorhabditis elegans)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - PP1 dephosphorylates RNA Pol II (Caenorhabditis elegans)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - RBBP6 activates CPSF complex (Caenorhabditis elegans)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
  - mRNA Splicing (Caenorhabditis elegans)
    - mRNA Splicing - Major Pathway (Caenorhabditis elegans)
      - Formation of the Spliceosomal Bact complex (Caenorhabditis elegans)
        
        Spliceosomal B complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal Bact complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of the Spliceosomal C complex containing intron lariat (Caenorhabditis elegans)
        
        Spliceosomal B* complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal C complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of the Spliceosomal C* complex (Caenorhabditis elegans)
        
        Spliceosomal C complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal C* complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of the Spliceosomal P complex and exon ligation (Caenorhabditis elegans)
        
        Spliceosomal C* complex [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal P complex [nucleoplasm] (Caenorhabditis elegans)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Caenorhabditis elegans)
        
        Alternative Splicing Factors [nucleoplasm] (Caenorhabditis elegans)
        
        shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)
        
        hrpa-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q22037

Gene Names

hrpa-1

Reference Genes

BioGPS Gene:177101 hrpa-1

ENSEMBL:WBGene00001999

KEGG:cel:CELE_F42A6.7 hrpa-1

Monarch:177101 hrpa-1

NCBI Gene:177101 hrpa-1

UCSC:Q22037 hrpa-1

Wormbase:WBGene00001999

Wormbase:WBGene00001999 hrpa-1

Reference Transcript

Other Identifiers

177101

GO:0000398

GO:0000781

GO:0003676

GO:0003723

GO:0003730

GO:0005634

GO:0005694

GO:0016071

GO:0031581

GO:0034330

GO:0071013

GO:0098687

GO:1990904

Participates

as a member of

shuttling HNRNPs [nucleoplasm] (Caenorhabditis elegans)

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)

as a component of

FGFR2 IIIc-specific splicing complex [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

hrpa-1 [nucleoplasm]

Inferred From

HNRNPA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001370723.1, NP_001367846.1, NP_001040945.1, NP_001379954.1

ENSEMBL

WBGene00001999, F42A6.7a.2, F42A6.7a.1, F42A6.7a.2, F42A6.7a.1

PRO

Q22037

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9XVS2 Q9XVS2			0.488	2

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