Reactome | orc-1 [nucleoplasm]

orc-1 [nucleoplasm]

Stable Identifier

R-CEL-68522

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

ORC1, Q9XX17

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Activation of the pre-replicative complex (Caenorhabditis elegans)
        
        Cdt1 is displaced from the pre-replicative complex (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Synthesis of DNA (Caenorhabditis elegans)
      - Switching of origins to a post-replicative state (Caenorhabditis elegans)
        
        Orc1 removal from chromatin (Caenorhabditis elegans)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)

DNA Replication (Caenorhabditis elegans)

- DNA Replication Pre-Initiation (Caenorhabditis elegans)
  - Activation of the pre-replicative complex (Caenorhabditis elegans)
    - Cdt1 is displaced from the pre-replicative complex (Caenorhabditis elegans)
      - MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
      - pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
  - Assembly of the pre-replicative complex (Caenorhabditis elegans)
    - Assembly of the ORC complex at the origin of replication (Caenorhabditis elegans)
      - Formation of ORC(1-5) complex (Caenorhabditis elegans)
        
        ORC(1-5):origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        ORC(1-5) [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        ORC1:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
      - ORC1 translocates to the nucleus (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)
- Synthesis of DNA (Caenorhabditis elegans)
  - Switching of origins to a post-replicative state (Caenorhabditis elegans)
    - Orc1 removal from chromatin (Caenorhabditis elegans)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XX17

Gene Names

orc-1

Reference Genes

BioGPS Gene:176486 orc-1

ENSEMBL:WBGene00012650

KEGG:cel:CELE_Y39A1A.12 orc-1

Monarch:176486 orc-1

NCBI Gene:176486 orc-1

UCSC:Q9XX17 orc-1

Wormbase:WBGene00012650

Wormbase:WBGene00012650 orc-1

Reference Transcript

RefSeq:NM_066946.7 orc-1

Other Identifiers

176486

GO:0000166

GO:0003677

GO:0003688

GO:0005524

GO:0005634

GO:0005664

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0033314

GO:0046872

Participates

as an output of

ORC1 translocates to the nucleus (Caenorhabditis elegans)

as a component of

Other forms of this molecule

phospho-orc-1 [cytosol]

phospho-orc-1 [nucleoplasm]

orc-1 [cytosol]

Inferred From

ORC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_499347.1

ENSEMBL

WBGene00012650, Y39A1A.12.1, Y39A1A.12.1

PRO

Q9XX17

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