Reactome | orc-4 [nucleoplasm]

orc-4 [nucleoplasm]

Stable Identifier

R-CEL-68519

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

ORC4, Q9XX16

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Activation of the pre-replicative complex (Caenorhabditis elegans)
        
        Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Synthesis of DNA (Caenorhabditis elegans)
      - Switching of origins to a post-replicative state (Caenorhabditis elegans)
        
        Orc1 removal from chromatin (Caenorhabditis elegans)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)

DNA Replication (Caenorhabditis elegans)

- DNA Replication Pre-Initiation (Caenorhabditis elegans)
  - Activation of the pre-replicative complex (Caenorhabditis elegans)
    - Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
    - Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
      - MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
      - pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
  - Assembly of the pre-replicative complex (Caenorhabditis elegans)
    - Assembly of the ORC complex at the origin of replication (Caenorhabditis elegans)
      - Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes (Caenorhabditis elegans)
        
        Orc1:Orc4:Orc5:Orc3:Orc2:origin [nucleoplasm] (Caenorhabditis elegans)
        
        Orc4:Orc5:Orc3:Orc2:origin [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        Orc4:Orc5:Orc3:Orc2:origin [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
- Synthesis of DNA (Caenorhabditis elegans)
  - Switching of origins to a post-replicative state (Caenorhabditis elegans)
    - Orc1 removal from chromatin (Caenorhabditis elegans)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDC6:ORC:origin complex [nucleoplasm] (Caenorhabditis elegans)
        
        ORC:origin of replication [nucleoplasm] (Caenorhabditis elegans)
        
        orc-4 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XX16

Gene Names

orc-4

Reference Genes

BioGPS Gene:176487 orc-4

ENSEMBL:WBGene00012651

KEGG Gene (Caenorhabditis elegans):CELE_Y39A1A.13 orc-4

Monarch:176487 orc-4

NCBI Gene:176487 orc-4

UCSC:Q9XX16 orc-4

Wormbase:WBGene00012651

Reference Transcript

RefSeq:NM_066947.5 orc-4

Other Identifiers

176487

18516793

186307_at

A_12_P104757

A_12_P146720

CE19132

CE_WBGene00012651_A

CE_WBGene00012651_B

CGZ0044722

GO:0000228

GO:0000808

GO:0003674

GO:0003677

GO:0003688

GO:0005575

GO:0005622

GO:0005634

GO:0005664

GO:0005694

GO:0006259

GO:0006260

GO:0006270

GO:0008150

GO:0009058

GO:0032991

GO:0034641

GO:0043226

WBGene00012651

Y39A1A.13

Y39A1A.13_1082-1141_0.920_7_C

Y39A1A.13_830-889_0.932_3_B

Y39A1A.13_941-1000_0.936_2_A

Y39A1A_13P00213

Y39A1A_13P00484

Y39A1A_13P00933

cea2.p.76234

Participant Of

hasComponent

Inferred From

ORC4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_499348.1

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