Reactome | cye-1 [nucleoplasm]

cye-1 [nucleoplasm]

Stable Identifier

R-CEL-68363

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

CCNE1, O01501

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1 Phase (Caenorhabditis elegans)
      - Cyclin D associated events in G1 (Caenorhabditis elegans)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
        
        Association of Rb with Cyclin E:Cdk2 complexes (Caenorhabditis elegans)
        
        CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        CAK-mediated phosphorylation of Cyclin E:Cdk2 (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
        
        Cyclin E:p-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Caenorhabditis elegans)
        
        Cyclin E:CDK2-mediated phosphorylation of RB1 (Caenorhabditis elegans)
        
        CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
        
        Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
      - SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
        
        Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)
    - Synthesis of DNA (Caenorhabditis elegans)
      - Switching of origins to a post-replicative state (Caenorhabditis elegans)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
        
        Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)

DNA Replication (Caenorhabditis elegans)

- Synthesis of DNA (Caenorhabditis elegans)
  - Switching of origins to a post-replicative state (Caenorhabditis elegans)
    - CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
      - Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)
        
        cye-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O01501

Gene Names

cye-1

Reference Genes

BioGPS Gene:172399 cye-1

CTD Gene:172399 cye-1

ENSEMBL:WBGene00000871

KEGG:cel:CELE_C37A2.4 cye-1

Monarch:172399 cye-1

NCBI Gene:172399 cye-1

UCSC:O01501 cye-1

Wormbase:WBGene00000871

Wormbase:WBGene00000871 cye-1

Reference Transcript

Other Identifiers

172399

GO:0000082

GO:0000278

GO:0000307

GO:0000785

GO:0005515

GO:0005634

GO:0005737

GO:0005814

GO:0005815

GO:0005856

GO:0007088

GO:0007281

GO:0008284

GO:0008406

GO:0009791

GO:0009792

GO:0010608

GO:0016538

GO:0022414

GO:0040026

GO:0042023

GO:0043226

GO:0045931

GO:0048856

GO:0051301

GO:0051321

GO:0051445

GO:0051729

GO:0097134

GO:1900087

GO:1904776

GO:1904781

Participates

as a component of

Other forms of this molecule

cye-1 [cytosol]

cye-1 [nucleoplasm]

cye-1 [cytosol]

Inferred From

Cyclin E [nucleoplasm] (Homo sapiens)

CCNE1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001021028.1, NP_001021027.1

ENSEMBL

WBGene00000871, C37A2.4a.1, C37A2.4a.1

PRO

O01501

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O61847	5	phospho-p-Y15-CDK2 [nucleoplasm] (R-CEL-187905) phospho-p-CDK2 [nucleoplasm] (R-CEL-68370) CDK2 [cytosol] (R-CEL-157440) CDK2 [nucleoplasm] (R-CEL-68365) phospho-p-T160-CDK2 [nucleoplasm] (R-CEL-187967)	0.556	3

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