Reactome | MARK3 [cytosol]

MARK3 [cytosol]

Stable Identifier

R-CEL-5672591

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q9TW45

Locations in the PathwayBrowser

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Signal Transduction (Caenorhabditis elegans)

- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - MAP2K and MAPK activation (Caenorhabditis elegans)
        
        Dissociation of RAS:RAF complex (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Caenorhabditis elegans)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
      - Negative regulation of MAPK pathway (Caenorhabditis elegans)
        
        BRAP binds KSR1:MARK3 (Caenorhabditis elegans)
        
        BRAP:KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
      - RAF activation (Caenorhabditis elegans)
        
        MARK3 phosphorylates KSR1 (Caenorhabditis elegans)
        
        KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        PP2A dephosphorylates KSR1 (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Caenorhabditis elegans)
        
        BRAP:KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Caenorhabditis elegans)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        Raf dimer inhibitors bind RAF heterodimers (Caenorhabditis elegans)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Caenorhabditis elegans)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Caenorhabditis elegans)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        YWHAB dimer dissociates from KSR1:MARK3 (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Caenorhabditis elegans)
        
        p-S311 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Caenorhabditis elegans)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Caenorhabditis elegans)
        
        MARK3 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9TW45

Reference Genes

BioGPS Gene:179912

ENSEMBL:WBGene00003916

KEGG:cel:CELE_H39E23.1

Monarch:179912

NCBI Gene:179912

UCSC:Q9TW45

Wormbase:WBGene00003916

Reference Transcript

Other Identifiers

179912

GO:0000166

GO:0000226

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005938

GO:0006468

GO:0007010

GO:0007163

GO:0009880

GO:0009949

GO:0016301

GO:0016740

GO:0030010

GO:0031625

GO:0032035

GO:0035556

GO:0040025

GO:0043186

GO:0043226

GO:0045167

GO:0046872

GO:0048856

GO:0050321

GO:0055059

GO:0071944

GO:0106310

GO:0140096

Participates

as a component of

Inferred From

MARK3 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

H39E23.1a.1, H39E23.1a.1, WBGene00003916

PRO

Q9TW45

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q21341	1	let-99 [cytosol] (R-CEL-200781)	0.524	2

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