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math-33 [nucleoplasm]
Stable Identifier
R-CEL-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
USP7, Q7JKC3
Locations in the PathwayBrowser
Expand all
DNA Repair (Caenorhabditis elegans)
Nucleotide Excision Repair (Caenorhabditis elegans)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Dual incision in TC-NER (Caenorhabditis elegans)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)
TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)
TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Formation of TC-NER Pre-Incision Complex (Caenorhabditis elegans)
Assembly of the pre-incision complex in TC-NER (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Deubiquitination (Caenorhabditis elegans)
Ub-specific processing proteases (Caenorhabditis elegans)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN localization (Caenorhabditis elegans)
USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)
math-33 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q7JKC3
Gene Names
math-33
Reference Genes
BioGPS Gene:179538 math-33
CTD Gene:179538 math-33
ENSEMBL:WBGene00010406
KEGG:cel:CELE_H19N07.2 math-33
Monarch:179538 math-33
NCBI Gene:179538 math-33
UCSC:Q7JKC3 math-33
Wormbase:WBGene00010406
Wormbase:WBGene00010406 math-33
Reference Transcript
RefSeq:NM_001028841.5 math-33
Other Identifiers
179538
GO:0004843
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006508
GO:0006511
GO:0008233
GO:0008234
GO:0008595
GO:0016579
GO:0016787
GO:0031581
GO:0031647
GO:0034330
GO:0051661
GO:0061629
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Caenorhabditis elegans)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 [nucleoplasm] (Caenorhabditis elegans)
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001024012.1
ENSEMBL
WBGene00010406
,
H19N07.2c.1
,
H19N07.2c.1
IntEnz
3.4.19.12
PRO
Q7JKC3
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