Reactome | cle-1 [extracellular region]

cle-1 [extracellular region]

Stable Identifier

R-CEL-2127347

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL4A3(29-1670), G5EGA4

Locations in the PathwayBrowser

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Extracellular matrix organization (Caenorhabditis elegans)

- Collagen formation (Caenorhabditis elegans)
  - Assembly of collagen fibrils and other multimeric structures (Caenorhabditis elegans)
    - Crosslinking of collagen fibrils (Caenorhabditis elegans)
      - Collagen type IV sulfilimine cross-linking by peroxidasin (Caenorhabditis elegans)
        
        Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
        
        Sulfilimine-containing collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) with or without sulfilimine cross-links [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
    - Formation of collagen networks (Caenorhabditis elegans)
      - Collagen networks [extracellular region] (Caenorhabditis elegans)
        
        Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
      - Network forming tropocollagens [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
- Degradation of the extracellular matrix (Caenorhabditis elegans)
  - Collagen degradation (Caenorhabditis elegans)
    - Collagen type IV degradation by MMP2,3,4,9,10,12 (Caenorhabditis elegans)
      - Cleaved collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Cleaved tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
      - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
    - Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Caenorhabditis elegans)
      - Cleaved collagen fibrils [extracellular region] (Caenorhabditis elegans)
        
        Cleaved collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Cleaved tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
- Fibronectin matrix formation (Caenorhabditis elegans)
  - FN1 binds Collagen types I-V, VII (Caenorhabditis elegans)
    - Collagen types I-V, VII [extracellular region] (Caenorhabditis elegans)
      - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
    - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Caenorhabditis elegans)
      - Collagen types I-V, VII [extracellular region] (Caenorhabditis elegans)
        
        Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
- Integrin cell surface interactions (Caenorhabditis elegans)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Caenorhabditis elegans)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Caenorhabditis elegans)
      - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Caenorhabditis elegans)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Caenorhabditis elegans)
        
        Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
- Laminin interactions (Caenorhabditis elegans)
  - Laminins:Nidogens binds collagen type IV networks (Caenorhabditis elegans)
    - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
      - Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
    - Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network [extracellular region] (Caenorhabditis elegans)
      - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
- Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Caenorhabditis elegans)
    - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
      - Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Caenorhabditis elegans)
      - Collagen type IV alpha3.alpha4.alpha5 network [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV) [extracellular region] (Caenorhabditis elegans)
        
        cle-1 [extracellular region] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EGA4

Gene Names

cle-1

Reference Genes

BioGPS Gene:172678 cle-1

CTD Gene:172678 cle-1

ENSEMBL:WBGene00000527

KEGG:cel:CELE_C36B1.1 cle-1

Monarch:172678 cle-1

NCBI Gene:172678 cle-1

UCSC:G5EGA4 cle-1

Wormbase:WBGene00000527

Wormbase:WBGene00000527 cle-1

Reference Transcript

RefSeq:NM_059957.3 cle-1

Other Identifiers

172678

GO:0001764

GO:0005198

GO:0005515

GO:0005576

GO:0005581

GO:0005587

GO:0005604

GO:0007271

GO:0007411

GO:0030020

GO:0030054

GO:0030312

GO:0031012

GO:0034330

GO:0035418

GO:0040039

GO:0045202

GO:0048870

GO:0050808

Participates

as a component of

Other forms of this molecule

cle-1 [endoplasmic reticulum lumen]

cle-1 [extracellular region]

Inferred From

Cleaved collagen alpha-3(IV) chains [extracellular region] (Homo sapiens)

Collagen alpha-3(IV) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL4A3(29-1670) [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_492358.3

ENSEMBL

WBGene00000527, C36B1.1d.1, C36B1.1d.1

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30632 ASNA			0.488	2
UniProt:Q21746	1	sgt-1 [cytosol] (R-CEL-5423595)	0.488	2

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