Reactome | phospho-crh-1 [nucleoplasm]

phospho-crh-1 [nucleoplasm]

Stable Identifier

R-CEL-199897

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

p-S63-ATF1, Q9U2I0

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-17 signaling (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Toll-like Receptor Cascades (Caenorhabditis elegans)
    - Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
      - Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
      - Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
      - MyD88-independent TLR4 cascade (Caenorhabditis elegans)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by NTRKs (Caenorhabditis elegans)
    - Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
      - Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9U2I0

Gene Names

crh-1

Reference Genes

BioGPS Gene:176597 crh-1

CTD Gene:176597 crh-1

ENSEMBL:WBGene00000793

KEGG:cel:CELE_Y41C4A.4 crh-1

Monarch:176597 crh-1

NCBI Gene:176597 crh-1

UCSC:Q9U2I0 crh-1

Wormbase:WBGene00000793

Wormbase:WBGene00000793 crh-1

Reference Transcript

Other Identifiers

176597

GO:0000785

GO:0000978

GO:0000981

GO:0000987

GO:0001223

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005667

GO:0006355

GO:0006357

GO:0007210

GO:0008340

GO:0035556

GO:0042802

GO:0043053

GO:0045944

GO:0141156

Participates

as an output of

MSK1 activates ATF1 (Caenorhabditis elegans)

Other forms of this molecule

crh-1 [nucleoplasm]

phospho-crh-1 [nucleoplasm]

Inferred From

p-S63-ATF1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 63 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001022859.1, NP_001255135.1, NP_001022861.1, NP_001022860.1, NP_001022862.1, NP_001255136.1, NP_001022863.1

ENSEMBL

WBGene00000793, Y41C4A.4b.1, Y41C4A.4b.1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9U2I0	4	phospho-crh-1 [nucleoplasm] (R-CEL-199897) crh-1 [nucleoplasm] (R-CEL-199900) crh-1 [nucleoplasm] (R-CEL-52777) phospho-crh-1 [nucleoplasm] (R-CEL-111910)	0.592	2

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