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HSP90AA1 [cytosol]
Stable Identifier
R-CEL-192864
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
Q18688
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to heat stress (Caenorhabditis elegans)
HSF1 activation (Caenorhabditis elegans)
Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)
HSF1:HSP90:PTGES3 [cytosol] (Caenorhabditis elegans)
HSP90:HSP90 [cytosol] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
HSP90:HSP90 [cytosol] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Metabolism (Caenorhabditis elegans)
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Programmed Cell Death (Caenorhabditis elegans)
Regulated Necrosis (Caenorhabditis elegans)
RIPK1-mediated regulated necrosis (Caenorhabditis elegans)
Regulation of necroptotic cell death (Caenorhabditis elegans)
MLKL binds HSP90:CDC37 (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
MLKL:HSP90:CDC37 [cytosol] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Drug-mediated inhibition of ERBB2 signaling (Caenorhabditis elegans)
ERBB2 binds TKIs (Caenorhabditis elegans)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q18688
Reference Genes
BioGPS Gene:179971
CTD Gene:179971
ENSEMBL:WBGene00000915
KEGG:cel:CELE_C47E8.5
Monarch:179971
NCBI Gene:179971
UCSC:Q18688
Wormbase:WBGene00000915
Wormbase:WBGene00000915
Reference Transcript
RefSeq:NM_074225.7
Other Identifiers
179971
GO:0000166
GO:0002119
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006457
GO:0006611
GO:0006886
GO:0006913
GO:0006935
GO:0008287
GO:0008340
GO:0009408
GO:0016787
GO:0016887
GO:0032991
GO:0034605
GO:0035259
GO:0040024
GO:0042802
GO:0045121
GO:0048471
GO:0048856
GO:0050821
GO:0050829
GO:0050920
GO:0051082
GO:0072542
GO:0098542
GO:0098772
GO:0101031
GO:0140662
GO:1990565
GO:1990634
Participates
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
HSP90 [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
HSP90AB1 [secretory granule lumen]
HSP90AA1 [secretory granule lumen]
HSP90AB1 [extracellular region]
HSP90AA1 [extracellular region]
HSP90AA1 [ficolin-1-rich granule lumen]
HSP90AB1 [ficolin-1-rich granule lumen]
HSP90AA1 [plasma membrane]
HSP90AB1 [cytosol]
HSP90AA1 [nucleoplasm]
HSP90AB1 [nucleoplasm]
Inferred From
HSP90AA1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_506626.1
ENSEMBL
C47E8.5.2
,
C47E8.5.1
,
C47E8.5.1
,
C47E8.5.2
,
WBGene00000915
PRO
Q18688
PDB
4I2Z
,
4GQT
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q11184
2
let-756 [extracellular region]
(R-CEL-189898)
let-756 [extracellular region]
(R-CEL-189856)
0.508
3
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