Reactome | EGF [extracellular region]

EGF [extracellular region]

Stable Identifier

R-CEL-179863

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

extracellular region

Synonyms

G5EFK8

Locations in the PathwayBrowser

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Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - PIP3 activates AKT signaling (Caenorhabditis elegans)
    - Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
        
        Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)
        
        Activated SRC,LCK,EGFR,INSR [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
        
        Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
      - Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
        
        RAS GEFs [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
- Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by PTK6 (Caenorhabditis elegans)
    - ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
      - Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
- Signaling by Nuclear Receptors (Caenorhabditis elegans)
  - ESR-mediated signaling (Caenorhabditis elegans)
    - Extra-nuclear estrogen signaling (Caenorhabditis elegans)
      - PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PTK2 binds activated EGFR (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by EGFR (Caenorhabditis elegans)
    - EGFR autophosphorylation (Caenorhabditis elegans)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - EGFR binds EGF ligand (Caenorhabditis elegans)
      - EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - EGFR dimerization (Caenorhabditis elegans)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - EGFR downregulation (Caenorhabditis elegans)
      - Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Binding of CBL to EGFR (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - CBL ubiquitinates Sprouty (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGFR phosphorylates EPS15 (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Phosphorylation of CBL (EGFR:CBL) (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - EGFR interacts with phospholipase C-gamma (Caenorhabditis elegans)
      - Active PLC-gamma1 dissociates from EGFR (Caenorhabditis elegans)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGFR activates PLC-gamma1 by phosphorylation (Caenorhabditis elegans)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Phospholipase C-gamma1 binds to the activated EGF receptor (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - GAB1 signalosome (Caenorhabditis elegans)
      - GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - GRB2 events in EGFR signaling (Caenorhabditis elegans)
      - GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - SHC1 events in EGFR signaling (Caenorhabditis elegans)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
  - Signaling by ERBB2 (Caenorhabditis elegans)
    - Downregulation of ERBB2 signaling (Caenorhabditis elegans)
      - MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:MATK [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
        
        Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18 [plasma membrane] (Caenorhabditis elegans)
        
        Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
      - Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - ERBB2 Regulates Cell Motility (Caenorhabditis elegans)
      - MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - PI3K events in ERBB2 signaling (Caenorhabditis elegans)
      - Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - SHC1 events in ERBB2 signaling (Caenorhabditis elegans)
      - SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)
      - EGF:EGFR:ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
      - EGF:EGFR:ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)
      - EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGFR:EGF-like ligands [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Clathrin recruits PIK3C2A (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EGF [extracellular region] (Caenorhabditis elegans)
        
        EGF [extracellular region] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EFK8

Reference Genes

BioGPS Gene:172750

CTD Gene:172750

ENSEMBL:WBGene00008779

KEGG:cel:CELE_F14B4.1

Monarch:172750

NCBI Gene:172750

UCSC:G5EFK8

Wormbase:WBGene00008779

Reference Transcript

RefSeq:NM_060073.6

Other Identifiers

172750

GO:0005509

GO:0005515

GO:0005886

GO:0006897

GO:0016020

GO:0016192

Participates

as a member of

Homologues of EGF [extracellular region] (Caenorhabditis elegans)

Other forms of this molecule

NID1(?-1247) [extracellular region]

NID1(29-?) [extracellular region]

NID1 [extracellular region]

EGF [clathrin-coated endocytic vesicle membrane]

Pro-EGF [extracellular region]

Pro-EGF [platelet alpha granule lumen]

Inferred From

EGF [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_492474.2

ENSEMBL

F14B4.1.1, F14B4.1.1, WBGene00008779

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