Reactome | PSMD14 [nucleoplasm]

PSMD14 [nucleoplasm]

Stable Identifier

R-CEL-174329

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

O76577

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle Checkpoints (Caenorhabditis elegans)
  - G1/S DNA Damage Checkpoints (Caenorhabditis elegans)
    - p53-Independent G1/S DNA Damage Checkpoint (Caenorhabditis elegans)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Caenorhabditis elegans)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)
- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
      - SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)

Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular response to chemical stress (Caenorhabditis elegans)
    - KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
      - Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Caenorhabditis elegans)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
      - Regulation of RUNX2 expression and activity (Caenorhabditis elegans)
        
        26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)
    - Transcriptional regulation by RUNX3 (Caenorhabditis elegans)
      - Regulation of RUNX3 expression and activity (Caenorhabditis elegans)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Hedgehog (Caenorhabditis elegans)
  - Hedgehog 'on' state (Caenorhabditis elegans)
    - GLI2,3 are degraded by the proteasome (Caenorhabditis elegans)
      - 26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid particle 2 [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP Lid Module 1 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)
        
        PSMD14 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O76577

Reference Genes

BioGPS Gene:173744

ENSEMBL:WBGene00004467

KEGG:cel:CELE_K07D4.3

Monarch:173744

NCBI Gene:173744

UCSC:O76577

Wormbase:WBGene00004467

Reference Transcript

RefSeq:NM_062311.9

Other Identifiers

173744

GO:0000502

GO:0005515

GO:0005634

GO:0005838

GO:0006508

GO:0008233

GO:0008237

GO:0008541

GO:0010623

GO:0012501

GO:0016787

GO:0030163

GO:0043161

GO:0046872

GO:0070628

GO:0140492

Participates

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

PSMD14 [secretory granule lumen]

PSMD14 [extracellular region]

PSMD14 [ficolin-1-rich granule lumen]

PSMD14 [cytosol]

Inferred From

PSMD14 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_494712.1

ENSEMBL

K07D4.3.1, K07D4.3.2, WBGene00004467, K07D4.3.1, K07D4.3.2

PRO

O76577

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O61792	5	rpn-8 [secretory granule lumen] (R-CEL-6801008) rpn-8 [extracellular region] (R-CEL-6806488) rpn-8 [ficolin-1-rich granule lumen] (R-CEL-6800406) rpn-8 [nucleoplasm] (R-CEL-174309) rpn-8 [cytosol] (R-CEL-68806)	0.712	5

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