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ITCH [cytosol]
Stable Identifier
R-BTA-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
ITCH, F1MGQ5
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Bos taurus)
ITCH polyubiquitinates TP73 (Bos taurus)
ITCH [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Bos taurus)
NOD1/2 Signaling Pathway (Bos taurus)
RIP2 is K63 polyubiquitinated (Bos taurus)
RIP2 ubiquitin ligases [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
ITCH polyubiquitinates MLKL at K50 (Bos taurus)
ITCH [cytosol] (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
MLKL binds ITCH (Bos taurus)
ITCH [cytosol] (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
Degradation of GLI1 by the proteasome (Bos taurus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB binds ITCH (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH bind and ubiquitnate GLI1 (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Hedgehog 'on' state (Bos taurus)
NUMB binds ITCH (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH binds GLI1 (Bos taurus)
GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
NUMB:ITCH ubiquitinates GLI1 (Bos taurus)
GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ub-GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ub-GLI is degraded by the proteasome (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ub-GLI1:NUMB:ITCH [cytosol] (Bos taurus)
NUMB:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Signaling by NOTCH (Bos taurus)
Signaling by NOTCH1 (Bos taurus)
Activated NOTCH1 Transmits Signal to the Nucleus (Bos taurus)
ITCH binds DTX (Bos taurus)
DTX:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ITCH ubiquitinates DTX (Bos taurus)
DTX:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Ub-DTX:ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB4 (Bos taurus)
Downregulation of ERBB4 signaling (Bos taurus)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Bos taurus)
WWP1/ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
WWP1/ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Bos taurus)
WWP1/ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Bos taurus)
WWP1/ITCH [cytosol] (Bos taurus)
ITCH [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MGQ5
Gene Names
ITCH
Reference Genes
BioGPS Gene:508431 ITCH
ENSEMBL:ENSBTAG00000000308.6
ENSEMBL:ENSBTAG00000000308.7 ITCH
Monarch:508431 ITCH
NCBI Gene:508431 ITCH
Reference Transcript
RefSeq:XM_010811429.2 ITCH
Other Identifiers
508431
GO:0003824
GO:0004842
GO:0005737
GO:0006511
GO:0016567
GO:0016740
GO:0030163
GO:0035519
GO:0036211
GO:0043161
GO:0061630
GO:0070534
GO:0070936
GO:0140096
Participates
as a member of
WWP1/ITCH [cytosol] (Bos taurus)
RIP2 ubiquitin ligases [cytosol] (Bos taurus)
as an input of
NUMB binds ITCH (Bos taurus)
ITCH binds DTX (Bos taurus)
MLKL binds ITCH (Bos taurus)
as a component of
NUMB:ITCH [cytosol] (Bos taurus)
Ub-DTX:ITCH [cytosol] (Bos taurus)
DTX:ITCH [cytosol] (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
as an output of
ITCH polyubiquitinates MLKL at K50 (Bos taurus)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
Other forms of this molecule
ITCH [cytosol]
Inferred From
ITCH [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_010809731.1
OpenTargets
ENSG00000078747
Ensembl
ENSBTAG00000000308
,
ENSBTAT00000000397
,
ENSBTAP00000000397
VGNC
30307
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