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EIF4G1 [cytosol]
Stable Identifier
R-BTA-72584
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
EIF4G1, F1MX04
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
ISG15 antiviral mechanism (Bos taurus)
Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)
EIF4F [cytosol] (Bos taurus)
EIF4G [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
eIF4F:mRNA [cytosol] (Bos taurus)
EIF4F [cytosol] (Bos taurus)
EIF4G [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Metabolism of RNA (Bos taurus)
Deadenylation-dependent mRNA decay (Bos taurus)
Deadenylation of mRNA (Bos taurus)
CCR4-NOT complex deadenylates mRNA (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Partially Deadenylated mRNA Complex [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)
Partially Deadenylated mRNA Complex [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Translatable mRNA Complex [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
PARN deadenylates mRNA (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Partially Deadenylated mRNA Complex [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Nonsense-Mediated Decay (NMD) (Bos taurus)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
mRNA Cleaved by SMG6 [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
mRNA Cleaved by SMG6 [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Bos taurus)
AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
AUF1 binds translation and heat shock proteins (Bos taurus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Translation (Bos taurus)
Eukaryotic Translation Initiation (Bos taurus)
Cap-dependent Translation Initiation (Bos taurus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Bos taurus)
Translation initiation complex formation (Bos taurus)
Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)
48S complex [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Bos taurus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Ribosomal scanning and start codon recognition (Bos taurus)
Ribosomal scanning (Bos taurus)
48S complex [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Start codon recognition (Bos taurus)
48S complex [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
L13a-mediated translational silencing of Ceruloplasmin expression (Bos taurus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Bos taurus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
MTOR signalling (Bos taurus)
mTORC1-mediated signalling (Bos taurus)
Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)
EIF4G1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MX04
Gene Names
EIF4G1
Reference Genes
ENSEMBL:ENSBTAG00000012881.6
ENSEMBL:ENSBTAG00000012881.7 EIF4G1
Other Identifiers
444858
GO:0000278
GO:0001662
GO:0003723
GO:0003729
GO:0003743
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005840
GO:0006412
GO:0006413
GO:0006446
GO:0006914
GO:0008135
GO:0008190
GO:0009059
GO:0010494
GO:0010507
GO:0010801
GO:0016281
GO:0030154
GO:0030182
GO:0030307
GO:0031047
GO:0031669
GO:0033138
GO:0034330
GO:0035278
GO:0036211
GO:0036493
GO:0042802
GO:0043226
GO:0045182
GO:0045666
GO:0048856
GO:0051247
GO:0065003
GO:0097009
GO:1900087
GO:1904377
GO:1905537
GO:1905606
Participates
as an input of
AUF1 binds translation and heat shock proteins (Bos taurus)
Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Bos taurus)
mRNA Cleaved by SMG6 [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Bos taurus)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Bos taurus)
eIF4F [cytosol] (Bos taurus)
Translatable mRNA Complex [cytosol] (Bos taurus)
Partially Deadenylated mRNA Complex [cytosol] (Bos taurus)
as an output of
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)
PARN deadenylates mRNA (Bos taurus)
CCR4-NOT complex deadenylates mRNA (Bos taurus)
as a member of
EIF4G [cytosol] (Bos taurus)
Other forms of this molecule
phospho-EIF4G1 [cytosol]
Inferred From
EIF4G1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000114867
Ensembl
ENSBTAP00000032150
,
ENSBTAT00000032213
,
ENSBTAG00000012881
VGNC
28415
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