Reactome | ORC1 [nucleoplasm]

ORC1 [nucleoplasm]

Stable Identifier

R-BTA-68522

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

ORC1, A0A140T8C7

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - G2/M Checkpoints (Bos taurus)
    - Activation of ATR in response to replication stress (Bos taurus)
      - Activation of claspin (Bos taurus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - Loading of claspin onto DNA during replication origin firing (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
- Cell Cycle, Mitotic (Bos taurus)
  - Mitotic G1 phase and G1/S transition (Bos taurus)
    - G1/S Transition (Bos taurus)
      - Activation of the pre-replicative complex (Bos taurus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        Cdt1 is displaced from the pre-replicative complex (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        DNA polymerase alpha:primase binds at the origin (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        DNA polymerase epsilon binds at the origin (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
  - S Phase (Bos taurus)
    - Synthesis of DNA (Bos taurus)
      - Switching of origins to a post-replicative state (Bos taurus)
        
        Orc1 removal from chromatin (Bos taurus)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)

DNA Replication (Bos taurus)

- DNA Replication Pre-Initiation (Bos taurus)
  - Activation of the pre-replicative complex (Bos taurus)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - Cdt1 is displaced from the pre-replicative complex (Bos taurus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - DNA polymerase alpha:primase binds at the origin (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - DNA polymerase epsilon binds at the origin (Bos taurus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        active pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)
      - MCM10:pre-replicative complex [nucleoplasm] (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
  - Assembly of the pre-replicative complex (Bos taurus)
    - Assembly of the ORC complex at the origin of replication (Bos taurus)
      - Formation of ORC(1-5) complex (Bos taurus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5) [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        ORC1:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - Formation of ORC(1-6) complex (Bos taurus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5) [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5) [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - ORC1 binds to H4K20me2 (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
      - ORC1 translocates to the nucleus (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
    - CDC6 association with the ORC:origin complex (Bos taurus)
      - CDC6 association with ORC(1-6) at replication origins (Bos taurus)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5) [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Bos taurus)
        
        ORC(1-5) [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)
- Synthesis of DNA (Bos taurus)
  - Switching of origins to a post-replicative state (Bos taurus)
    - Orc1 removal from chromatin (Bos taurus)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
        
        pre-replicative complex [nucleoplasm] (Bos taurus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Bos taurus)
        
        ORC:origin of replication [nucleoplasm] (Bos taurus)
        
        ORC1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A140T8C7

Gene Names

ORC1

Reference Genes

ENSEMBL:ENSBTAG00000002719.6

UCSC:A0A140T8C7 ORC1

Other Identifiers

513523

Bt.2111.1.S1_a_at

GO:0000781

GO:0000808

GO:0003682

GO:0005524

GO:0005654

GO:0005664

GO:0006270

GO:0016787

GO:0016887

Participates

as an input of

ORC1 binds to H4K20me2 (Bos taurus)

as an output of

ORC1 translocates to the nucleus (Bos taurus)

as a component of

Other forms of this molecule

phospho-ORC1 [cytosol]

phospho-ORC1 [nucleoplasm]

ORC1 [cytosol]

Inferred From

ORC1 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAP00000048350, ENSBTAG00000002719, ENSBTAT00000052505

VGNC

32446

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