Reactome | GNAI2 [plasma membrane]

GNAI2 [plasma membrane]

Stable Identifier

R-BTA-55435

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

GNAI2, A7MBH9

Locations in the PathwayBrowser

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Hemostasis (Bos taurus)

- Platelet activation, signaling and aggregation (Bos taurus)
  - Signal amplification (Bos taurus)
    - ADP signalling through P2Y purinoceptor 12 (Bos taurus)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Bos taurus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GDP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GDP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Bos taurus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
      - Gi activation by P2Y purinoceptor 12 (Bos taurus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GDP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)

Neuronal System (Bos taurus)

- Transmission across Chemical Synapses (Bos taurus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
    - GABA receptor activation (Bos taurus)
      - GABA B receptor activation (Bos taurus)
        
        Activation of GABAB receptors (Bos taurus)
        
        Adenylate cyclase inhibitory pathway (Bos taurus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GDP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        Dissociation of the Gi alpha:G olf complex (Bos taurus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GDP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GDP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Bos taurus)
        
        G alpha (i): GTP [plasma membrane] (Bos taurus)
        
        G alpha (i) [plasma membrane] (Bos taurus)
        
        GNAI2 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A7MBH9

Gene Names

GNAI2

Reference Genes

BioGPS Gene:281791 GNAI2

ENSEMBL:ENSBTAG00000020645.6

KEGG Gene (Bos taurus):281791 GNAI2

Monarch:281791 GNAI2

NCBI Gene:281791 GNAI2

Reference Transcript

RefSeq:NM_001101040.1 GNAI2

Other Identifiers

281791

GO:0000166

GO:0001664

GO:0001973

GO:0003824

GO:0003924

GO:0005525

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005834

GO:0005856

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0007213

GO:0007214

GO:0008283

GO:0008284

GO:0016787

GO:0019001

GO:0023052

GO:0030425

GO:0030496

GO:0031410

GO:0031683

GO:0043226

GO:0044297

GO:0045202

GO:0051301

GO:0098992

Participates

as a candidate of

G alpha (i,o) (candidates) [plasma membrane] (Bos taurus)

as a member of

G alpha (i) [plasma membrane] (Bos taurus)

Inferred From

GNAI2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001094510.1

OpenTargets

ENSG00000114353

Ensembl

ENSBTAP00000027511, ENSBTAT00000027511, ENSBTAG00000020645

VGNC

29450

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