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FADD [cytosol]
Stable Identifier
R-BTA-54639
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
FADD, Q645M6
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TRIF-mediated programmed cell death (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TLR4-induced ripoptosome assembly (Bos taurus)
FADD [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Caspase activation via extrinsic apoptotic signalling pathway (Bos taurus)
Caspase activation via Death Receptors in the presence of ligand (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
Dimerization of procaspase-8 (Bos taurus)
FAS-mediated dimerization of procaspase-8 (Bos taurus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TNF-mediated dimerization of procaspase-8 (Bos taurus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRAIL-mediated dimerization of procaspase-8 (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
Regulation by c-FLIP (Bos taurus)
Caspase-8 and FLIP(L) processing at DISC (Bos taurus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
CASP8 activity is inhibited (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
FLIP(S) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
RIPK1 is cleaved by CASP8 (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
FasL/ CD95L signaling (Bos taurus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
FasL:Fas binds FADD (Bos taurus)
FADD [cytosol] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
FADD [cytosol] (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
RIPK1 is cleaved by CASP8 (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)
FADD [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
FADD [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q645M6
Gene Names
FADD
Reference Genes
BioGPS Gene:493720 FADD
ENSEMBL:ENSBTAG00000018274
ENSEMBL:ENSBTAG00000018274.6 FADD
KEGG Gene (Bos taurus):493720 FADD
Monarch:493720 FADD
NCBI Gene:493720 FADD
Reference Transcript
RefSeq:NM_001007816.1 FADD
Other Identifiers
GO:0001916
GO:0002020
GO:0002376
GO:0002821
GO:0005123
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0007155
GO:0007165
GO:0008625
GO:0012501
GO:0023052
GO:0030154
GO:0031264
GO:0031265
GO:0032729
GO:0032757
GO:0032760
GO:0032813
GO:0033077
GO:0035591
GO:0035877
GO:0036462
GO:0042104
GO:0042802
GO:0042981
GO:0043029
GO:0043065
GO:0043123
GO:0045087
GO:0045089
GO:0045651
GO:0045862
GO:0045944
GO:0048535
GO:0048536
GO:0048538
GO:0048856
GO:0048870
GO:0051607
GO:0060090
GO:0060340
GO:0060546
GO:0065003
GO:0070236
GO:0071260
GO:0071550
GO:0089720
GO:0097049
GO:0097190
GO:0097191
GO:0097192
GO:0097342
GO:0097527
GO:0098542
GO:1900119
GO:2000454
GO:2001238
Participates
as a component of
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Bos taurus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
as an input of
FasL:Fas binds FADD (Bos taurus)
TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)
TLR4-induced ripoptosome assembly (Bos taurus)
Inferred From
FADD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001007817.1
OpenTargets
ENSG00000168040
Ensembl
ENSBTAT00000024322
,
ENSBTAG00000018274
,
ENSBTAP00000024322
VGNC
28700
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