Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
XIAP [cytosol]
Stable Identifier
R-BTA-50849
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
XIAP, G3MWG5
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Bos taurus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAF3 binds BAFFR:BAFF (Bos taurus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAFs bind RANK:RANKL (Bos taurus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Bos taurus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF2:cIAP1,2 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Apoptotic factor-mediated response (Bos taurus)
Cytochrome c-mediated apoptotic response (Bos taurus)
Activation of caspases through apoptosome-mediated cleavage (Bos taurus)
Cleavage of Procaspase-3 by the apoptosome (Bos taurus)
XIAP [cytosol] (Bos taurus)
Cleavage of Procaspase-7 by the apoptosome (Bos taurus)
XIAP [cytosol] (Bos taurus)
Formation of apoptosome (Bos taurus)
Regulation of the apoptosome activity (Bos taurus)
XIAP binds CASP9 (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP:apoptosome [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
SMAC, XIAP-regulated apoptotic response (Bos taurus)
SEPT4 binds XIAP (Bos taurus)
SEPT4 dimer:XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
SMAC (DIABLO) binds to IAPs (Bos taurus)
SMAC (DIABLO) binds XIAP (Bos taurus)
DIABLO dimer:XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
SMAC binds XIAP:Caspase-7 (Bos taurus)
DIABLO:XIAP:Caspase-7 [cytosol] (Bos taurus)
XIAP:Caspase-7 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP:Caspase-7 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Bos taurus)
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)
DIABLO dimer:XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
DIABLO:XIAP:Caspase-7 [cytosol] (Bos taurus)
XIAP:Caspase-7 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP binds CASP3 (Bos taurus)
DIABLO:XIAP:Caspase-3 [cytosol] (Bos taurus)
XIAP:Caspase-3 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP:Caspase-3 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP binds CASP7 (Bos taurus)
XIAP [cytosol] (Bos taurus)
XIAP:Caspase-7 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
CLIP3 and CYLD bind TNF signaling complex (Bos taurus)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
K63polyUb-RIPK1 is deubiquitinated (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
OPTN recruits CYLD to the TNFR1 complex (Bos taurus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Bos taurus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Bos taurus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN localization (Bos taurus)
PTEN undergoes monoubiquitination (Bos taurus)
XIAP,NEDD4 [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:G3MWG5
Gene Names
XIAP
Reference Genes
ENSEMBL:ENSBTAG00000040350.4
UCSC:G3MWG5 XIAP
Other Identifiers
GO:0002376
GO:0003824
GO:0004842
GO:0005634
GO:0005737
GO:0006974
GO:0010804
GO:0012501
GO:0016740
GO:0031398
GO:0032481
GO:0032496
GO:0042742
GO:0042802
GO:0042981
GO:0043027
GO:0043066
GO:0043123
GO:0043226
GO:0046330
GO:0051402
GO:0060785
GO:0061135
GO:0061630
GO:0070427
GO:0070431
GO:0070534
GO:0090263
GO:0098542
GO:0098772
GO:0120283
GO:0140096
GO:1902530
Participates
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Bos taurus)
as a candidate of
XIAP,NEDD4 [cytosol] (Bos taurus)
BIRC2,3,4 [cytosol] (Bos taurus)
as an input of
SEPT4 binds XIAP (Bos taurus)
SMAC (DIABLO) binds XIAP (Bos taurus)
XIAP binds CASP3 (Bos taurus)
XIAP binds CASP7 (Bos taurus)
XIAP binds CASP9 (Bos taurus)
as a component of
SEPT4 dimer:XIAP [cytosol] (Bos taurus)
XIAP:apoptosome [cytosol] (Bos taurus)
XIAP:Caspase-7 [cytosol] (Bos taurus)
DIABLO dimer:XIAP [cytosol] (Bos taurus)
XIAP:Caspase-3 [cytosol] (Bos taurus)
This entity regulates
Negatively
Cleavage of Procaspase-7 by the apoptosome
(Bos taurus)
Cleavage of Procaspase-3 by the apoptosome
(Bos taurus)
Other forms of this molecule
XIAP [nucleoplasm]
XIAP [cytosol]
Inferred From
XIAP [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000053449
,
ENSBTAT00000061054
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text