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PI3K delta [cytosol]
Stable Identifier
R-BTA-508241
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-stimulation by CD28 (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K binds CD28 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Co-stimulation by ICOS (Bos taurus)
PI3K binds ICOS (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-regulatory subunits [cytosol]
(Bos taurus)
PIK3CD [plasma membrane]
(Bos taurus)
Participates
as a member of
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
Inferred From
PI3K delta [cytosol]
(Homo sapiens)
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