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PIK3CD [plasma membrane]
Stable Identifier
R-BTA-392274
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
PIK3CD, E1BE66
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
p-CD19:VAV binds PI3K and GRB2 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
K63polyUb-PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BE66
Gene Names
PIK3CD
Reference Genes
BioGPS Gene:504531 PIK3CD
ENSEMBL:ENSBTAG00000018984.5
Monarch:504531 PIK3CD
NCBI Gene:504531 PIK3CD
Reference Transcript
RefSeq:XM_010813245.2 PIK3CD
RefSeq:XM_005216942.2 PIK3CD
RefSeq:XM_005216943.3 PIK3CD
RefSeq:XM_005216944.3 PIK3CD
Other Identifiers
504531
GO:0000166
GO:0001938
GO:0002376
GO:0003824
GO:0005524
GO:0005737
GO:0005886
GO:0005942
GO:0005943
GO:0006629
GO:0010595
GO:0010628
GO:0012501
GO:0014065
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0023052
GO:0030335
GO:0033031
GO:0035004
GO:0035005
GO:0036092
GO:0038089
GO:0043491
GO:0046854
GO:0046934
GO:0048015
GO:0048856
GO:0048870
GO:1905278
Participates
as a component of
K63polyUb-PI3K delta [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
Other forms of this molecule
PIK3CD [cytosol]
Inferred From
PIK3CD [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_005217000.1
,
XP_005217001.1
,
XP_010811547.1
,
XP_005216999.1
OpenTargets
ENSG00000171608
Ensembl
ENSBTAT00000071502
,
ENSBTAT00000025274
,
ENSBTAP00000025274
,
ENSBTAG00000018984
,
ENSBTAP00000064363
VGNC
32891
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