Reactome | TAS1R2 [plasma membrane]

TAS1R2 [plasma membrane]

Stable Identifier

R-BTA-444622

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

TAS1R2, F1N5V2

Locations in the PathwayBrowser

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Sensory Perception (Bos taurus)

- Sensory perception of taste (Bos taurus)
  - Sensory perception of sweet, bitter, and umami (glutamate) taste (Bos taurus)
    - Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)
      - TAS1R2:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
      - TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (i) signalling events (Bos taurus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
      - The Ligand:GPCR:Gi complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Bos taurus)
      - T1R2/T1R3 dimer is a sweet taste receptor (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Bos taurus)
        
        TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)
        
        TAS1R2 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:F1N5V2

Gene Names

TAS1R2

Reference Genes

BioGPS Gene:529847 TAS1R2

ENSEMBL:ENSBTAG00000015246.6

KEGG:bta:529847 TAS1R2

Monarch:529847 TAS1R2

NCBI Gene:529847 TAS1R2

UCSC:F1N5V2 TAS1R2

Reference Transcript

RefSeq:NM_001206529.3 TAS1R2

Other Identifiers

529847

GO:0001582

GO:0004930

GO:0007186

GO:0008527

GO:0016020

GO:0032467

GO:0033041

GO:0043235

GO:0050877

GO:0050916

GO:1903767

Participates

as a component of

TAS1R2:TAS1R3 [plasma membrane] (Bos taurus)

Inferred From

TAS1R2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001193458.3

ENSEMBL

ENSBTAP00000038055, ENSBTAG00000015246, ENSBTAT00000038240

VGNC

35608