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TAS1R2 [plasma membrane]
Stable Identifier
R-HSA-444622
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 1 member 2, TS1R2_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)
TAS1R2:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TE23 TAS1R2
Gene Names
TAS1R2, GPR71, T1R2, TR2
Chain
signal peptide:1-19, chain:20-839
Reference Genes
BioGPS Gene:80834 TAS1R2
COSMIC (genes):TAS1R2 TAS1R2
CTD Gene:80834 TAS1R2
dbSNP Gene:80834 TAS1R2
ENSEMBL:ENSG00000179002 TAS1R2
HGNC:14905 TAS1R2
KEGG:hsa:80834 TAS1R2
Monarch:80834 TAS1R2
NCBI Gene:80834 TAS1R2
OMIM:606226 TAS1R2
UCSC:Q8TE23 TAS1R2
Reference Transcript
RefSeq:NM_152232.2 TAS1R2
Other Identifiers
11742451_at
1553529_PM_at
1553529_at
16682450
2399290
2399291
2399292
2399293
2399294
2399295
2399296
2399298
2399299
2399301
4046029
4046030
4046031
4046032
4046033
7912968
80834
GE904517
GO:0001582
GO:0004930
GO:0005886
GO:0007186
GO:0008527
GO:0016020
GO:0032467
GO:0033041
GO:0043235
GO:0050877
GO:0050909
GO:0050916
GO:0060089
GO:1903767
HMNXSV003047497
Hs2.404128.1.S1_3p_at
ILMN_1697141
PH_hs_0019152
TC01006346.hg
Participates
as a component of
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
Inferred To
tas1r1 [plasma membrane]
(Danio rerio)
TAS1R2 [plasma membrane]
(Bos taurus)
TAS1R2 [plasma membrane]
(Sus scrofa)
Ghost homologue of TAS1R2 [plasma membrane]
(Canis familiaris)
Tas1r2 [plasma membrane]
(Mus musculus)
Tas1r2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_689418.2
Guide to Pharmacology - Targets
657
ENSEMBL
ENST00000375371
,
ENSP00000364520
OpenTargets
ENSG00000179002
HPA
ENSG00000179002-TAS1R2
PRO
Q8TE23
Pharos - Targets
Q8TE23
GlyGen
Q8TE23
HMDB Protein
HMDBP10824
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