Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A

Stable Identifier
R-BTA-391521
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A
Beta-tubulin folding intermediates generated via ATP-dependent interaction with TriC/CCT are captured by tubulin-specific chaperones A and D (TBCA and TBCD) (Tian et al. 1996, Tian et al. 1997) in a reversible reaction forming tubulin intermediate/cofactor complexes Factor A:beta tubulin or Factor D:beta tubulin. TBCD is involved in the tubulin-folding pathway, acting as a GTPase activating protein (GAP) for beta-tubulin. The ADP-ribosylation factor-like protein 2 (ARL2) is able to down-regulate TBCD specifically, thus preventing microtuble disruption (Bhamidipati et al. 2000, Tian et al. 2010).
Literature References
PubMed ID Title Journal Year
9265649 Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors

Tian, G, Lewis, SA, Feierbach, B, Stearns, T, Rommelaere, H, Ampe, C, Cowan, NJ

J Cell Biol 1997
Participants
Input
Output
Orthologous Events
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A (Homo sapiens)
Authored
Cowan, NJ  (2009-01-21)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-02-23)
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