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Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A
Stable Identifier
R-HSA-389956
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Beta-tubulin folding intermediates generated via ATP-dependent interaction with TriC/CCT are captured by tubulin-specific chaperones A and D (TBCA and TBCD) (Tian et al. 1996, Tian et al. 1997) in a reversible reaction forming tubulin intermediate/cofactor complexes Factor A:beta tubulin or Factor D:beta tubulin. TBCD is involved in the tubulin-folding pathway, acting as a GTPase activating protein (GAP) for beta-tubulin. The ADP-ribosylation factor-like protein 2 (ARL2) is able to down-regulate TBCD specifically, thus preventing microtuble disruption (Bhamidipati et al. 2000, Tian et al. 2010).
Participants
Input
GTP:beta-tubulin folding intermediate [cytosol]
(Homo sapiens)
TBCA [cytosol]
(Homo sapiens)
Output
cofactor A:GTP:beta-tubulin folding intermediate [cytosol]
(Homo sapiens)
Participates
as an event of
Post-chaperonin tubulin folding pathway (Homo sapiens)
Inferred From
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A (Bos taurus)
Authored
Matthews, L (2008-12-01)
Reviewed
Cowan, NJ (2009-01-21)
Created
Matthews, L (2009-01-22)
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