Reactome | PRKAB1 [cytosol]

PRKAB1 [cytosol]

Stable Identifier

R-BTA-380968

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

PRKAB1, Q5BIS9

Locations in the PathwayBrowser

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Autophagy (Bos taurus)

- Macroautophagy (Bos taurus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)
    - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
      - p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - Thr-180 of ULK1 is phosphorylated (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - ULK complex translocates to the ER (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - ULK1 phosphorylates Beclin-1 (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - p-AMPK:AMP binds the ULK complex (Bos taurus)
    - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
      - p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
    - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
      - p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Metabolic Genes (Bos taurus)
        
        SESN1,2,3 bind AMPK (Bos taurus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK beta [cytosol] (Bos taurus)
        
        PRKAB1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q5BIS9

Gene Names

PRKAB1

Reference Genes

BioGPS Gene:534107 PRKAB1

ENSEMBL:ENSBTAG00000005940

KEGG:bta:534107 PRKAB1

Monarch:534107 PRKAB1

NCBI Gene:534107 PRKAB1

UCSC:Q5BIS9 PRKAB1

Reference Transcript

Other Identifiers

534107

Bt.20256.1.S1_at

GO:0005515

GO:0005634

GO:0031588

GO:0031669

GO:0035878

GO:0048856

GO:0120162

Participates

as a member of

AMPK beta [cytosol] (Bos taurus)

Other forms of this molecule

PRKAB1 [endoplasmic reticulum lumen]

PRKAB1 [nucleoplasm]

Inferred From

PRKAB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_059732059.1, NP_001019729.1, XP_005217938.1

ENSEMBL

ENSBTAT00000007798, ENSBTAP00000007798, ENSBTAG00000005940

VGNC

33319

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