Reactome | COL6A1 [extracellular region]

COL6A1 [extracellular region]

Stable Identifier

R-BTA-2127538

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL6A1, E1BI98

Locations in the PathwayBrowser

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Extracellular matrix organization (Bos taurus)

- Collagen formation (Bos taurus)
  - Assembly of collagen fibrils and other multimeric structures (Bos taurus)
    - Formation of collagen networks (Bos taurus)
      - Collagen networks [extracellular region] (Bos taurus)
        
        Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
      - Network forming tropocollagens [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
  - Collagen biosynthesis and modifying enzymes (Bos taurus)
    - Secretion of collagens (Bos taurus)
      - Collagens and tropocollagens [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
- Degradation of the extracellular matrix (Bos taurus)
  - Collagen degradation (Bos taurus)
    - Collagen type VI degradation by MMP2,9,11 (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
- ECM proteoglycans (Bos taurus)
  - BGN binds Collagen types I, VI, (IX) (Bos taurus)
    - BGN:Collagen types I, VI, (IX) [extracellular region] (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
    - Collagen type VI fibril [extracellular region] (Bos taurus)
      - Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
  - DCN binds collagen I, II, III, VI fibrils (Bos taurus)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Bos taurus)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Bos taurus)
        
        Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        COL6A1 [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BI98

Gene Names

COL6A1

Reference Genes

BioGPS Gene:511422 COL6A1

ENSEMBL:ENSBTAG00000011802

KEGG Gene (Bos taurus):511422 COL6A1

Monarch:511422 COL6A1

NCBI Gene:511422 COL6A1

Reference Transcript

RefSeq:NM_001143865.1 COL6A1

Other Identifiers

511422

Bt.13681.2.S1_at

Bt.23508.1.A1_at

GO:0005575

GO:0005576

GO:0005615

GO:0031012

GO:0062023

Participant Of

hasComponent

Tropocollagen type VI [extracellular region]

Other forms of this molecule

COL6A1 [endoplasmic reticulum lumen]

COL6A1 [extracellular region]

Inferred From

3x4Hyp-3Hyp-GalHyl-COL6A1 [extracellular region] (Homo sapiens)

Collagen alpha-1(VI) chains [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_001137337.1

Target Pathogen

5b354852be737e166372e6bb

OpenTargets

ENSG00000142156

Ensembl

ENSBTAT00000015668, ENSBTAG00000011802, ENSBTAP00000015668

VGNC

27570