Reactome | p-Y371-CBL:GRB2 [cytosol]

p-Y371-CBL:GRB2 [cytosol]

Stable Identifier

R-BTA-182964

Type

Complex

Species

Bos taurus

Compartment

cytosol

Locations in the PathwayBrowser

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Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - Epsin family proteins bind ubiquitinated cargo (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

as an input of

Inferred From

p-Y371-CBL:GRB2 [cytosol] (Homo sapiens)

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