Reactome | GRB2-1 [cytosol]

GRB2-1

Stable Identifier

R-BTA-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

Q3T0F9

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Axon guidance (Bos taurus)
  - NCAM signaling for neurite out-growth (Bos taurus)
    - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)
      - Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
        
        pFAK:Grb2:Sos [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)
      - GRB2-1 [cytosol] (Bos taurus)
      - Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
        
        pFAK:Grb2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)
      - Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
        
        pFAK:Grb2:Sos [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
        
        pFAK:Grb2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
  - RET signaling (Bos taurus)
    - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - p-5Y-RET complexes bind GRB2 (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - GRB2-1 [cytosol] (Bos taurus)
    - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Costimulation by the CD28 family (Bos taurus)
    - CD28 co-stimulation (Bos taurus)
      - CD28 dependent Vav1 pathway (Bos taurus)
        
        Activation of Rac1 by pVav1 (Bos taurus)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
        
        CD28:Grb2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Activation of Vav1 (Bos taurus)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
        
        CD28:Grb2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
        
        CD28:Grb2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Grb2 binds CD28 (Bos taurus)
        
        CD28:Grb2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Translocation of Vav1 to CD28 (Bos taurus)
        
        CD28:Grb2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
        
        CD28:Grb2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
  - Signaling by the B Cell Receptor (BCR) (Bos taurus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
      - Signalosomes assemble at the activated BCR (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)
        
        BLNK:GRB2:SOS1:CIN85:CBL [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-2 family signaling (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Interleukin-15 signaling (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        GRB2:pY-GAB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Regulation of signaling by CBL (Bos taurus)
        
        CBL ubiquitinates PI3K (Bos taurus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
- Innate Immune System (Bos taurus)
  - DAP12 interactions (Bos taurus)
    - DAP12 signaling (Bos taurus)
      - Activation of RAC1 by VAV2/3 (Bos taurus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of BTK by p-SYK (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-SYK/p-BTK [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of SLP-76 by p-SYK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Release of p-PLCG1 (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - FCERI mediated Ca+2 mobilization (Bos taurus)
      - Autophosphorylation of BTK/ITK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Hydrolysis of PIP2 by PLCG (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of TEC kinases by p-SYK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Activation of RAC1 by VAV (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Autophosphorylation of PAK (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation and activation of VAV (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of SLP-76 by p-SYK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of VAV to p-SLP-76 (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
      - PI3K associates with phosphorylated GAB2 (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
        
        GRB2-1:SOS1 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - Attachment of preexisting mother filament and initiation of branching (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
        
        SH3 domain proteins [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
        
        SH3 domain proteins [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Detachment of WASP/WAVE (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
        
        SH3 domain proteins [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
        
        SH3 domain proteins [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - Phosphorylation of WASP/N-WASP (Bos taurus)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
        
        SH3 domain proteins [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
        
        SH3 domain proteins [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated vesicle membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
        
        p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        GRB2-1 [cytosol] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - Epsin family proteins bind ubiquitinated cargo (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)