Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GRB2 [cytosol]
Stable Identifier
R-BTA-74686
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
GRB2-1, Q3T0F9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
NCAM signaling for neurite out-growth (Bos taurus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
RET signaling (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-5Y-RET complexes bind GRB2 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent Vav1 pathway (Bos taurus)
Activation of Vav1 (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
CD28:Grb2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
CD28:Grb2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Grb2 binds CD28 (Bos taurus)
CD28:Grb2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3:GRB2 binds SOS1 (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
GRB2:p-Y-GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
GRB2:p-Y-GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
GRB2:p-Y-GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin-15 signaling (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
GRB2:GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
GRB2:p-Y-GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
GRB2:p-Y-GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
GRB2:p-Y-GAB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
PI3K associates with phosphorylated GAB2 (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
EGFR Transactivation by Gastrin (Bos taurus)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
CBL binds to GRB2 (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Localization of CBL:GRB2 to the membrane (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2 events in EGFR signaling (Bos taurus)
GRB2-1 binds SOS1 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC1 events in EGFR signaling (Bos taurus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by ERBB2 (Bos taurus)
GRB2 events in ERBB2 signaling (Bos taurus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by ERBB4 (Bos taurus)
SHC1 events in ERBB4 signaling (Bos taurus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR1 (Bos taurus)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR2 (Bos taurus)
Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR3 (Bos taurus)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIK3R1 [cytosol] (Bos taurus)
GRB2:GAB1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p-Y371-CBL:GRB2 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
GRB2-1 binds SOS1 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS-mediated signalling (Bos taurus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signal attenuation (Bos taurus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)
GRB2-1:p-4S-SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Bos taurus)
GRB2-1:p-4S-SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)
GRB2-1:p-4S-SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:p-4S-SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Signalling to RAS (Bos taurus)
GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Activation of RAS by p-KIT bound SOS1 (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Indirect recruitment of GAB2 to p-KIT (Bos taurus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Phosphorylation of GAB2 by SFKs (Bos taurus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Regulation of KIT signaling (Bos taurus)
Recruitment of CBL to KIT (Bos taurus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SOS-mediated signalling (Bos taurus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
SHC-related events triggered by IGF1R (Bos taurus)
GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
GRB2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3T0F9
Gene Names
GRB2
Reference Genes
BioGPS Gene:535298 GRB2
ENSEMBL:ENSBTAG00000004736
KEGG Gene (Bos taurus):535298 GRB2
Monarch:535298 GRB2
NCBI Gene:535298 GRB2
Reference Transcript
RefSeq:XM_010816566.1 GRB2
RefSeq:NM_001034630.1 GRB2
Other Identifiers
535298
GO:0000003
GO:0001784
GO:0003674
GO:0005154
GO:0005168
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005768
GO:0005794
GO:0005886
GO:0005911
GO:0006464
GO:0006810
GO:0006950
GO:0007010
GO:0007165
GO:0007173
GO:0008150
GO:0008180
GO:0008286
GO:0009790
GO:0012506
GO:0016020
GO:0016192
GO:0017124
GO:0019899
GO:0019901
GO:0019903
GO:0019904
GO:0022607
GO:0030154
GO:0030674
GO:0030838
GO:0031410
GO:0031532
GO:0031623
GO:0032991
GO:0042770
GO:0042802
GO:0043226
GO:0043408
GO:0043560
GO:0046875
GO:0048646
GO:0048856
GO:0060670
GO:0065003
GO:0070436
GO:0071479
GO:2000379
Participant Of
input
CBL binds to GRB2
Grb2 binds CD28
GRB2 is indirectly recruited to p-KIT through SHP2
GRB2-1 binds SOS1
p-5Y-RET complexes bind GRB2
Recruitment of Grb2 to pFAK:NCAM1
SPRY2 binds GRB2
The SHC1:SHIP1 complex is stabilized by GRB2
hasComponent
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane]
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane]
Active FLT3: GRB2 [plasma membrane]
CBL:GRB2 [cytosol]
CD28:Grb2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol]
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol]
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane]
GRB2-1:p-4S-SOS1 [cytosol]
GRB2-1:SOS1 [cytosol]
GRB2:GAB1 [cytosol]
GRB2:GAB2 [cytosol]
GRB2:p-SHP2:p-KIT complex [plasma membrane]
GRB2:p-Y-GAB2 [cytosol]
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane]
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane]
p-Y371-CBL:GRB2 [cytosol]
pFAK:Grb2 [cytosol]
pFAK:Grb2:Sos [cytosol]
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane]
output
PPTN11 dephosphorylates SPRY2
Inferred From
GRB2-1 [cytosol] (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_010814868.1
,
NP_001029802.1
OpenTargets
ENSG00000177885
Ensembl
ENSBTAG00000004736
,
ENSBTAP00000006216
,
ENSBTAT00000006216
VGNC
29631
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text