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Shelterin complex [nucleoplasm]
Stable Identifier
R-BTA-174898
Type
Complex
Species
Bos taurus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Chromosome Maintenance (Bos taurus)
Telomere Maintenance (Bos taurus)
Extension of Telomeres (Bos taurus)
Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
Disassociation of Processive Complex and Completed Telomere End (Bos taurus)
Extended And Processed Telomere End [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Polymerase switching on the C-strand of the telomere (Bos taurus)
Formation of Processive Complex on the C-strand of the telomere (Bos taurus)
Processive complex loaded on telomere [nucleoplasm] (Bos taurus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Bos taurus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive synthesis on the C-strand of the telomere (Bos taurus)
Formation of C-strand Okazaki fragments (Bos taurus)
Processive complex loaded on telomere [nucleoplasm] (Bos taurus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Joining of adjacent Okazaki fragments of the C-strand (Bos taurus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Removal of the Flap Intermediate from the C-strand (Bos taurus)
RPA binds to the Flap on the C-strand (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Recruitment of DNA2 endonuclease to the C strand (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Removal of remaining Flap from the C-strand (Bos taurus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomere C-strand synthesis initiation (Bos taurus)
DNA polymerase:primase binds G-strand of the telomere (Bos taurus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Bos taurus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Bos taurus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomere Extension By Telomerase (Bos taurus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
CDK2:CCNA phosphorylates TERF2 (Bos taurus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Elongation Of The Telomeric Chromosome End (Bos taurus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Elongation of Extended Telomeric Chromosome End (Bos taurus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Bos taurus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Inhibition of DNA recombination at telomere (Bos taurus)
Histone H3.3 deposition at telomere (Bos taurus)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Bos taurus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Packaging Of Telomere Ends (Bos taurus)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Bos taurus)
Extended And Processed Telomere End [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
Telomere shortening during replicative exhaustion (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Base-Excision Repair, AP Site Formation (Bos taurus)
Depurination (Bos taurus)
Cleavage of the damaged purine (Bos taurus)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
Recognition and association of DNA glycosylase with site containing an affected purine (Bos taurus)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Shelterin complex [nucleoplasm] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
ACD [nucleoplasm]
(Bos taurus)
POT1 [nucleoplasm]
(Bos taurus)
TERF1 homodimer [nucleoplasm]
(Bos taurus)
TERF2 homodimer [nucleoplasm]
(Bos taurus)
x 2
TERF2IP [nucleoplasm]
(Bos taurus)
TINF2 [nucleoplasm]
(Bos taurus)
Participates
as a component of
AP-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Bos taurus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Bos taurus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Bos taurus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Bos taurus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Bos taurus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Bos taurus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Bos taurus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Bos taurus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Bos taurus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Bos taurus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End [nucleoplasm] (Bos taurus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Bos taurus)
as an output of
Telomere shortening during replicative exhaustion (Bos taurus)
as an input of
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Bos taurus)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Bos taurus)
Inferred From
Shelterin complex [nucleoplasm]
(Homo sapiens)
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