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SMAD7 [cytosol]
Stable Identifier
R-BTA-173478
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SMAD7, E1B8T7
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Bos taurus)
SMAD7:SMURF2 [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Bos taurus)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Bos taurus)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by BMP (Bos taurus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Bos taurus)
I-SMAD:SMURF [cytosol] (Bos taurus)
I-SMAD [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
I-SMAD:SMURF [cytosol] (Bos taurus)
I-SMAD [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Bos taurus)
I-SMAD [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Bos taurus)
I-SMAD [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
I-Smad competes with R-Smad1/5/8 for type I receptor (Bos taurus)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Bos taurus)
I-SMAD [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
I-SMAD [cytosol] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
Degradation of TGF-beta receptor complex (Bos taurus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Bos taurus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Bos taurus)
SMAD7 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1B8T7
Gene Names
SMAD7
Reference Genes
BioGPS Gene:535916 SMAD7
ENSEMBL:ENSBTAG00000012441.6
ENSEMBL:ENSBTAG00000012441.7 SMAD7
KEGG Gene (Bos taurus):535916 SMAD7
Monarch:535916 SMAD7
NCBI Gene:535916 SMAD7
Reference Transcript
RefSeq:NM_001192865.1 SMAD7
Other Identifiers
GO:0005634
GO:0005667
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0007179
GO:0009653
GO:0023052
GO:0030154
GO:0043226
GO:0046872
GO:0048856
GO:0060395
GO:0070411
GO:0071144
GO:0098772
GO:0140416
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Bos taurus)
SMAD7:SMURF2 [cytosol] (Bos taurus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Bos taurus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Bos taurus)
as a member of
I-SMAD [cytosol] (Bos taurus)
as an input of
BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)
Other forms of this molecule
SMAD7 [nucleoplasm]
Inferred From
SMAD7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001179794.1
OpenTargets
ENSG00000101665
Ensembl
ENSBTAG00000012441
,
ENSBTAT00000046721
,
ENSBTAP00000043987
VGNC
34980
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