Reactome | NDUFA9 [mitochondrial matrix]

NDUFA9 [mitochondrial matrix]

Stable Identifier

R-BTA-163942

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial matrix

Synonyms

NDUFA9, P34943

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- Aerobic respiration and respiratory electron transport (Bos taurus)
  - Respiratory electron transport (Bos taurus)
    - Complex I biogenesis (Bos taurus)
      - IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - NDUF subunits bind to form the IP subcomplex (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Bos taurus)
      - Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA9:FAD [mitochondrial matrix] (Bos taurus)
        
        NDUFA9 [mitochondrial matrix] (Bos taurus)

External Reference Information

External Reference

UniProt:P34943

Gene Names

NDUFA9

Reference Genes

BioGPS Gene:404188 NDUFA9

ENSEMBL:ENSBTAG00000005465

KEGG:bta:404188 NDUFA9

Monarch:404188 NDUFA9

NCBI Gene:404188 NDUFA9

UCSC:P34943 NDUFA9

Reference Transcript

RefSeq:NM_205817.1 NDUFA9

Other Identifiers

404188

Bt.5541.1.S1_at

GO:0003954

GO:0005739

GO:0005743

GO:0005759

GO:0007623

GO:0016491

GO:0031966

GO:0044877

GO:0045271

Participates

as a component of

NDUFA9:FAD [mitochondrial matrix] (Bos taurus)

Inferred From

NDUFA9 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_991386.1

ENSEMBL

ENSBTAG00000005465, ENSBTAP00000096905, ENSBTAT00000115294

VGNC

56233

PDB

7R46, 7R48, 7R4D, 7QSD, 7QSL, 7DKF, 7R45, 7R47, 7DGS, 8Q46, 7R4C, 7QSK, 8Q1P, 7DGR, 8Q45, 8Q48, 7R4G, 7R4F, 8Q0M, 8Q1U, 7QSN, 7DH0, 7DGQ, 8Q49, 8Q47, 7QSM, 7QSO, 8Q25, 8Q0Q, 8Q0O, 8Q0F, 8Q0J, 7R42, 8Q1Y, 7R44, 7R41, 7R43, 8Q0A, 8Q4A, 7DGZ

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