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MIB2 [cytosol]
Stable Identifier
R-BTA-1472879
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
MIB2, E1BBN5
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
MIB2 binds CFLAR (Bos taurus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 binds CYLD (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2:CYLD:UBE2D2 [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)
MIB2 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 ubiquitinates CFLAR (Bos taurus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2:CYLD:UBE2D2 [cytosol] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)
MIB2 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Bos taurus)
MIB2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BBN5
Gene Names
MIB2
Reference Genes
ENSEMBL:ENSBTAG00000010720.6
UCSC:E1BBN5 MIB2
Other Identifiers
538270
GO:0000151
GO:0003824
GO:0004842
GO:0005768
GO:0005769
GO:0005886
GO:0016567
GO:0016740
GO:0031410
GO:0043226
GO:0061630
GO:0140096
Participates
as an input of
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)
MIB2 binds CFLAR (Bos taurus)
MIB2 binds CYLD (Bos taurus)
as a component of
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Bos taurus)
MIB2:CYLD:UBE2D2 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Bos taurus)
as an output of
MIB2 ubiquitinates CFLAR (Bos taurus)
MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
Inferred From
MIB2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000014195
,
ENSBTAT00000014195
VGNC
31456
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