Reactome | MIB2 [cytosol]

MIB2 [cytosol]

Stable Identifier

R-BTA-1472879

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

MIB2, E1BBN5

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:E1BBN5

Gene Names

MIB2

Reference Genes

BioGPS Gene:538270 MIB2

ENSEMBL:ENSBTAG00000010720.6

Monarch:538270 MIB2

NCBI Gene:538270 MIB2

UCSC:E1BBN5 MIB2

Reference Transcript

RefSeq:XM_024976798.2 MIB2
RefSeq:XM_024976799.2 MIB2

Other Identifiers

538270

Bt.1722.2.S1_at

Bt.1722.3.S1_a_at

GO:0000151

GO:0003824

GO:0004842

GO:0005515

GO:0005768

GO:0005769

GO:0005886

GO:0008270

GO:0016567

GO:0016740

GO:0046872

GO:0061630

GO:0140096

Participates

as an input of

MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)
MIB2 binds CFLAR (Bos taurus)
MIB2 binds CYLD (Bos taurus)

as a component of

TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Bos taurus)
MIB2:CYLD:UBE2D2 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Bos taurus)

as an output of

MIB2 ubiquitinates CFLAR (Bos taurus)
MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)

as a member of

E3 ligases in proteasomal degradation [cytosol] (Bos taurus)

Other forms of this molecule

MIB2 [Golgi membrane]

Inferred From

MIB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_024832566.1, XP_024832567.1

ENSEMBL

ENSBTAP00000014195, ENSBTAG00000010720, ENSBTAT00000014195

VGNC

31456