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TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]
Stable Identifier
R-BTA-9816109
Type
Complex
Species
Bos taurus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
MIB2 [cytosol]
(Bos taurus)
RIPK1 [cytosol]
(Bos taurus)
TNF-α trimer:TNFR1 trimer [plasma membrane]
(Bos taurus)
x 3
TRADD [cytosol]
(Bos taurus)
x 3
TRAF2 [cytosol]
(Bos taurus)
Participates
as an output of
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)
This entity regulates
Negatively
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1
(Bos taurus)
Inferred From
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]
(Homo sapiens)
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