Reactome | p-T,Y MAPK dimers [cytosol]

Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to heat stress (Bos taurus)
    - Regulation of HSF1-mediated heat shock response (Bos taurus)
      - Constitutive phosphorylation by pERK1/2 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)

Developmental Biology (Bos taurus)

- MITF-M-regulated melanocyte development (Bos taurus)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
    - MAPK-dependent phosphorylation of KARS (Bos taurus)
      - p-T,Y MAPK dimers [cytosol] (Bos taurus)
- Signaling by NODAL (Bos taurus)
  - The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
    - p-T,Y MAPK dimers [cytosol] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
        
        MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
        
        The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Interferon Signaling (Bos taurus)
    - Interferon gamma signaling (Bos taurus)
      - IFNG signaling activates MAPKs (Bos taurus)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - p-ERK phosphorylates WAVEs and ABI (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)

Programmed Cell Death (Bos taurus)

- Apoptosis (Bos taurus)
  - Intrinsic Pathway for Apoptosis (Bos taurus)
    - Apoptotic factor-mediated response (Bos taurus)
      - Cytochrome c-mediated apoptotic response (Bos taurus)
        
        Formation of apoptosome (Bos taurus)
        
        Regulation of the apoptosome activity (Bos taurus)
        
        CASP9 is phosphorylated at T412 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Intracellular signaling by second messengers (Bos taurus)
  - PIP3 activates AKT signaling (Bos taurus)
    - Negative regulation of the PI3K/AKT network (Bos taurus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
        
        IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)
        
        PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        MAPKs phosphorylate PP2A (Bos taurus)
        
        PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF-independent MAPK1/3 activation (Bos taurus)
      - Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - PEA15 binds MAPK monomers and dimers (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - p-T,Y MAPKs dimerize (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - Negative regulation of MAPK pathway (Bos taurus)
        
        Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        Negative feedback regulation of MAPK pathway (Bos taurus)
        
        Activated MAPKs phosphorylate BRAF (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        PTPN7 binds p-T,Y-MAPK (Bos taurus)
        
        PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
        
        PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - PEA15 binds MAPK monomers and dimers (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - p-T,Y MAPKs dimerize (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by FGFR (Bos taurus)
    - Signaling by FGFR1 (Bos taurus)
      - Negative regulation of FGFR1 signaling (Bos taurus)
        
        Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        Spry regulation of FGF signaling (Bos taurus)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
    - Signaling by FGFR2 (Bos taurus)
      - Negative regulation of FGFR2 signaling (Bos taurus)
        
        Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        Spry regulation of FGF signaling (Bos taurus)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
    - Signaling by FGFR3 (Bos taurus)
      - Negative regulation of FGFR3 signaling (Bos taurus)
        
        Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        Spry regulation of FGF signaling (Bos taurus)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
    - Signaling by FGFR4 (Bos taurus)
      - Negative regulation of FGFR4 signaling (Bos taurus)
        
        Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        Spry regulation of FGF signaling (Bos taurus)
        
        SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
  - Signaling by NTRKs (Bos taurus)
    - Signaling by NTRK1 (TRKA) (Bos taurus)
      - Signalling to ERKs (Bos taurus)
        
        Prolonged ERK activation events (Bos taurus)
        
        Frs2-mediated activation (Bos taurus)
        
        p-T,Y MAPK dimers translocate to nucleus (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
        
        p-T,Y MAPKs dimerize (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
  - Signaling by Rho GTPases (Bos taurus)
    - RHO GTPase Effectors (Bos taurus)
      - RHO GTPases Activate NADPH Oxidases (Bos taurus)
        
        MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - RHO GTPases Activate WASPs and WAVEs (Bos taurus)
        
        p-ERK phosphorylates WAVEs and ABI (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
- Signaling by TGFB family members (Bos taurus)
  - Signaling by Activin (Bos taurus)
    - The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
      - p-T,Y MAPK dimers [cytosol] (Bos taurus)
  - Signaling by TGF-beta Receptor Complex (Bos taurus)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
        
        MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
        
        The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
        
        p-T,Y MAPK dimers [cytosol] (Bos taurus)