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p-T,Y MAPK dimers [cytosol]
Stable Identifier
R-BTA-1268261
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-ERK dimer
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
Constitutive phosphorylation by pERK1/2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
MAPK-dependent phosphorylation of KARS (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by NODAL (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon gamma signaling (Bos taurus)
IFNG signaling activates MAPKs (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Apoptotic factor-mediated response (Bos taurus)
Cytochrome c-mediated apoptotic response (Bos taurus)
Formation of apoptosome (Bos taurus)
Regulation of the apoptosome activity (Bos taurus)
CASP9 is phosphorylated at T412 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
MAPKs phosphorylate PP2A (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
PEA15 binds MAPK monomers and dimers (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Negative feedback regulation of MAPK pathway (Bos taurus)
Activated MAPKs phosphorylate BRAF (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
PTPN7 binds p-T,Y-MAPK (Bos taurus)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
PEA15 binds MAPK monomers and dimers (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
p-T,Y MAPK dimers translocate to nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by Activin (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
Participants
members
p-T202, Y204 MAPK3 dimer [cytosol]
(Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol]
(Bos taurus)
Participates
as an input of
PTPN7 binds p-T,Y-MAPK (Bos taurus)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)
p-T,Y MAPK dimers translocate to nucleus (Bos taurus)
as a component of
PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
as an output of
MAPKs phosphorylate PP2A (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
as a member of
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
This entity regulates
Negatively
The SMAD2/3:SMAD4 complex transfers to the nucleus
(Bos taurus)
Positively
SPRY2 is serine phosphorylated in response to MAPK activation
(Bos taurus)
Inferred From
p-T,Y MAPK dimers [cytosol]
(Homo sapiens)
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