Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HIF1A [cytosol]
Stable Identifier
R-BTA-1234131
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
2xHP-HIF1A, A0JND0
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
HIF1A [cytosol] (Bos taurus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
HIF1A [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0JND0
Gene Names
HIF1A
Reference Genes
BioGPS Gene:281814 HIF1A
ENSEMBL:ENSBTAG00000020935.6
KEGG:bta:281814 HIF1A
Monarch:281814 HIF1A
NCBI Gene:281814 HIF1A
UCSC:A0JND0 HIF1A
Reference Transcript
RefSeq:NM_174339.3 HIF1A
Participates
as a member of
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
as an output of
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
Other forms of this molecule
HIF1A [cytosol]
HIF1A [nucleoplasm]
phospho-HIF1A [cytosol]
phospho-HIF1A [cytosol]
HIF1A [cytosol]
HIF1A [nucleoplasm]
Inferred From
2xHP-HIF1A [cytosol]
(Homo sapiens)
Modified Residues
Name
monohydroxylated proline at 402 (in Homo sapiens)
Coordinate
402
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 564 (in Homo sapiens)
Coordinate
564
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
RefSeq
NP_776764.2
VGNC
29848
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text