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hydroxyPro-HIF-alpha [cytosol]
Stable Identifier
R-BTA-1234106
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
Synonyms
HIF-alpha with Hydroxylated Proline, HIF1A, HIF2A, HIF3A with Hydroxyproline
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Participants
members
EPAS1 [cytosol]
(Bos taurus)
HIF1A [cytosol]
(Bos taurus)
HIF3A [cytosol]
(Bos taurus)
Participates
as an input of
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
Inferred From
hydroxyPro-HIF-alpha [cytosol]
(Homo sapiens)
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