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TBM [endoplasmic reticulum lumen]
Stable Identifier
R-ALL-9838902
Type
ChemicalDrug
Compartment
endoplasmic reticulum lumen
Synonyms
tolbutamide
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Dictyostelium discoideum
Mus musculus
Rattus norvegicus
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Cytochrome P450 - arranged by substrate type (Bos taurus)
Xenobiotics (Bos taurus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)
TBM [endoplasmic reticulum lumen]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Xenobiotics (Caenorhabditis elegans)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Caenorhabditis elegans)
TBM [endoplasmic reticulum lumen]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Xenobiotics (Dictyostelium discoideum)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)
TBM [endoplasmic reticulum lumen]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
TBM [endoplasmic reticulum lumen]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Cytochrome P450 - arranged by substrate type (Mus musculus)
Xenobiotics (Mus musculus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)
TBM [endoplasmic reticulum lumen]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Xenobiotics (Rattus norvegicus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Rattus norvegicus)
TBM [endoplasmic reticulum lumen]
Literature References
PubMed ID
Title
Journal
Year
13459201
Studies on the mechanism of tolbutamide hypoglycemia in animal and human subjects
RECANT, L
,
FISCHER, GL
Ann. N. Y. Acad. Sci.
1957
10526167
The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure
Babenko, AP
,
Gonzalez, G
,
Bryan, J
FEBS Lett.
1999
External Reference Information
External Reference
tolbutamide [Guide to Pharmacology:6848]
Participates
as an input of
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Caenorhabditis elegans)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Rattus norvegicus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Other forms of this molecule
tolbutamide [extracellular region]
Disease
Name
Identifier
Synonyms
type 2 diabetes mellitus
DOID:9352
non-insulin-dependent diabetes mellitus, NIDDM, type II diabetes mellitus
Cross References
Mondo
0005148
ChEBI
27999
,
27999
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