CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation

Stable Identifier
R-HSA-211988
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
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CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation
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Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.

Literature References
PubMed ID Title Journal Year
2025243 Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

Veronese, ME, Mackenzie, PI, Doecke, CJ, McManus, ME, Miners, JO, Birkett, DJ

Biochem Biophys Res Commun 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane]
Physical Entity
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Danio rerio)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Gallus gallus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)