Reactome | CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation

CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation

Stable Identifier

R-HSA-211988

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation

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Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.

Literature References

PubMed ID	Title	Journal	Year
2025243	Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9 McManus, ME, Miners, JO, Veronese, ME, Mackenzie, PI, Doecke, CJ, Birkett, DJ	Biochem Biophys Res Commun	1991