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What is Reactome ?
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G analog [endolysosome lumen]
Stable Identifier
R-ALL-9824768
Type
Set [DefinedSet]
Compartment
endolysosome lumen
Synonyms
G, dG, 2',3'-cGMP, 8-OHdG, guanosine or guanosine derivative
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
G or G analog binds C-ter TLR7 dimer (Bos taurus)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Bos taurus)
G analog [endolysosome lumen]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
G or G analog binds C-ter TLR7 dimer (Canis familiaris)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Canis familiaris)
G analog [endolysosome lumen]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Regulation of TLR by endogenous ligand (Gallus gallus)
G or G analog binds C-ter TLR7 dimer (Gallus gallus)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Gallus gallus)
G analog [endolysosome lumen]
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
Defective regulation of TLR7 by endogenous ligand (Homo sapiens)
G or G analog binds C-ter TLR7 GoF variant (Homo sapiens)
G analog [endolysosome lumen]
TLR7 variant:G analog [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
G or G analog binds C-ter TLR7 dimer (Homo sapiens)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Regulation of TLR by endogenous ligand (Mus musculus)
G or G analog binds C-ter TLR7 dimer (Mus musculus)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Mus musculus)
G analog [endolysosome lumen]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Regulation of TLR by endogenous ligand (Rattus norvegicus)
G or G analog binds C-ter TLR7 dimer (Rattus norvegicus)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Rattus norvegicus)
G analog [endolysosome lumen]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Regulation of TLR by endogenous ligand (Sus scrofa)
G or G analog binds C-ter TLR7 dimer (Sus scrofa)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Sus scrofa)
G analog [endolysosome lumen]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Toll-like Receptor Cascades (Xenopus tropicalis)
Regulation of TLR by endogenous ligand (Xenopus tropicalis)
G or G analog binds C-ter TLR7 dimer (Xenopus tropicalis)
G analog [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Xenopus tropicalis)
G analog [endolysosome lumen]
Participants
members
2',3'-cyclic GMP [endolysosome lumen]
Gua-Rib [endolysosome lumen]
8-OHdG [endolysosome lumen]
dG [endolysosome lumen]
Participates
as a component of
TLR7 variant:G analog [endolysosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Gallus gallus)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Xenopus tropicalis)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Sus scrofa)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Mus musculus)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Bos taurus)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Rattus norvegicus)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Canis familiaris)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
as an input of
G or G analog binds C-ter TLR7 GoF variant (Homo sapiens)
G or G analog binds C-ter TLR7 dimer (Gallus gallus)
G or G analog binds C-ter TLR7 dimer (Xenopus tropicalis)
G or G analog binds C-ter TLR7 dimer (Sus scrofa)
G or G analog binds C-ter TLR7 dimer (Bos taurus)
G or G analog binds C-ter TLR7 dimer (Canis familiaris)
G or G analog binds C-ter TLR7 dimer (Mus musculus)
G or G analog binds C-ter TLR7 dimer (Homo sapiens)
G or G analog binds C-ter TLR7 dimer (Rattus norvegicus)
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