Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Gua-Rib [endolysosome lumen]
Stable Identifier
R-ALL-9824730
Type
Chemical Compound [SimpleEntity]
Compartment
endolysosome lumen
Synonyms
guanosine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
G or G analog binds C-ter TLR7 dimer (Bos taurus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Bos taurus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
G or G analog binds C-ter TLR7 dimer (Canis familiaris)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Canis familiaris)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Regulation of TLR by endogenous ligand (Gallus gallus)
G or G analog binds C-ter TLR7 dimer (Gallus gallus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Gallus gallus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
Defective regulation of TLR7 by endogenous ligand (Homo sapiens)
G or G analog binds C-ter TLR7 GoF variant (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TLR7 variant:G analog [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
G or G analog binds C-ter TLR7 dimer (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
G analog:C-ter TLR7 dimer [endolysosome membrane] (Homo sapiens)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Regulation of TLR by endogenous ligand (Mus musculus)
G or G analog binds C-ter TLR7 dimer (Mus musculus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Mus musculus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Regulation of TLR by endogenous ligand (Rattus norvegicus)
G or G analog binds C-ter TLR7 dimer (Rattus norvegicus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Rattus norvegicus)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Regulation of TLR by endogenous ligand (Sus scrofa)
G or G analog binds C-ter TLR7 dimer (Sus scrofa)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Sus scrofa)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Toll-like Receptor Cascades (Xenopus tropicalis)
Regulation of TLR by endogenous ligand (Xenopus tropicalis)
G or G analog binds C-ter TLR7 dimer (Xenopus tropicalis)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
G analog:C-ter TLR7 dimer [endolysosome membrane] (Xenopus tropicalis)
G analog [endolysosome lumen]
Gua-Rib [endolysosome lumen]
External Reference Information
External Reference
guanosine [ChEBI:16750]
Participates
as a member of
G analog [endolysosome lumen]
Other forms of this molecule
Gua-Rib [lysosomal lumen]
Gua-Rib [extracellular region]
Gua-Rib [cytosol]
Cross References
Guide to Pharmacology - Ligands
4567
COMPOUND
C00387
PubChem Substance
8144918
HMDB Metabolite
HMDB0000133
ZINC
ZINC000001550030
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
