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sirolimus [cytosol]
Stable Identifier
R-ALL-9678687
Type
ChemicalDrug
Compartment
cytosol
Synonyms
AY-22989, Rapamune®, rapamycin, WY-090217
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
MTOR signalling (Bos taurus)
mTORC1-mediated signalling (Bos taurus)
FKBP1A binds sirolimus (Bos taurus)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Bos taurus)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)
FKBP1A:sirolimus [cytosol] (Bos taurus)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
FKBP1A:sirolimus [cytosol] (Bos taurus)
sirolimus [cytosol]
Signal Transduction (Caenorhabditis elegans)
MTOR signalling (Caenorhabditis elegans)
mTORC1-mediated signalling (Caenorhabditis elegans)
FKBP1A binds sirolimus (Caenorhabditis elegans)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Caenorhabditis elegans)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)
FKBP1A:sirolimus [cytosol] (Caenorhabditis elegans)
sirolimus [cytosol]
Signal Transduction (Canis familiaris)
MTOR signalling (Canis familiaris)
mTORC1-mediated signalling (Canis familiaris)
FKBP1A binds sirolimus (Canis familiaris)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Canis familiaris)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)
FKBP1A:sirolimus [cytosol] (Canis familiaris)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)
FKBP1A:sirolimus [cytosol] (Canis familiaris)
sirolimus [cytosol]
Signal Transduction (Danio rerio)
MTOR signalling (Danio rerio)
mTORC1-mediated signalling (Danio rerio)
FKBP1A binds sirolimus (Danio rerio)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Danio rerio)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Danio rerio)
FKBP1A:sirolimus [cytosol] (Danio rerio)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)
FKBP1A:sirolimus [cytosol] (Danio rerio)
sirolimus [cytosol]
Signal Transduction (Dictyostelium discoideum)
MTOR signalling (Dictyostelium discoideum)
mTORC1-mediated signalling (Dictyostelium discoideum)
FKBP1A binds sirolimus (Dictyostelium discoideum)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Dictyostelium discoideum)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Dictyostelium discoideum)
FKBP1A:sirolimus [cytosol] (Dictyostelium discoideum)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Dictyostelium discoideum)
FKBP1A:sirolimus [cytosol] (Dictyostelium discoideum)
sirolimus [cytosol]
Signal Transduction (Drosophila melanogaster)
MTOR signalling (Drosophila melanogaster)
mTORC1-mediated signalling (Drosophila melanogaster)
FKBP1A binds sirolimus (Drosophila melanogaster)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Drosophila melanogaster)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)
FKBP1A:sirolimus [cytosol] (Drosophila melanogaster)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)
FKBP1A:sirolimus [cytosol] (Drosophila melanogaster)
sirolimus [cytosol]
Signal Transduction (Gallus gallus)
MTOR signalling (Gallus gallus)
mTORC1-mediated signalling (Gallus gallus)
FKBP1A binds sirolimus (Gallus gallus)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Gallus gallus)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)
FKBP1A:sirolimus [cytosol] (Gallus gallus)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)
FKBP1A:sirolimus [cytosol] (Gallus gallus)
sirolimus [cytosol]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
FKBP1A binds sirolimus (Homo sapiens)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Homo sapiens)
sirolimus [cytosol]
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
FKBP1A binds sirolimus (Homo sapiens)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Homo sapiens)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
FKBP1A:sirolimus [cytosol] (Homo sapiens)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
FKBP1A:sirolimus [cytosol] (Homo sapiens)
sirolimus [cytosol]
Signal Transduction (Mus musculus)
MTOR signalling (Mus musculus)
mTORC1-mediated signalling (Mus musculus)
FKBP1A binds sirolimus (Mus musculus)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Mus musculus)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)
FKBP1A:sirolimus [cytosol] (Mus musculus)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)
FKBP1A:sirolimus [cytosol] (Mus musculus)
sirolimus [cytosol]
Signal Transduction (Rattus norvegicus)
MTOR signalling (Rattus norvegicus)
mTORC1-mediated signalling (Rattus norvegicus)
FKBP1A binds sirolimus (Rattus norvegicus)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Rattus norvegicus)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)
FKBP1A:sirolimus [cytosol] (Rattus norvegicus)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)
FKBP1A:sirolimus [cytosol] (Rattus norvegicus)
sirolimus [cytosol]
Signal Transduction (Saccharomyces cerevisiae)
MTOR signalling (Saccharomyces cerevisiae)
mTORC1-mediated signalling (Saccharomyces cerevisiae)
FKBP1A binds sirolimus (Saccharomyces cerevisiae)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Saccharomyces cerevisiae)
sirolimus [cytosol]
Signal Transduction (Schizosaccharomyces pombe)
MTOR signalling (Schizosaccharomyces pombe)
mTORC1-mediated signalling (Schizosaccharomyces pombe)
FKBP1A binds sirolimus (Schizosaccharomyces pombe)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Schizosaccharomyces pombe)
sirolimus [cytosol]
Signal Transduction (Sus scrofa)
MTOR signalling (Sus scrofa)
mTORC1-mediated signalling (Sus scrofa)
FKBP1A binds sirolimus (Sus scrofa)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Sus scrofa)
sirolimus [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)
FKBP1A:sirolimus [cytosol] (Sus scrofa)
sirolimus [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)
FKBP1A:sirolimus [cytosol] (Sus scrofa)
sirolimus [cytosol]
Signal Transduction (Xenopus tropicalis)
MTOR signalling (Xenopus tropicalis)
mTORC1-mediated signalling (Xenopus tropicalis)
FKBP1A binds sirolimus (Xenopus tropicalis)
sirolimus [cytosol]
FKBP1A:sirolimus [cytosol] (Xenopus tropicalis)
sirolimus [cytosol]
External Reference Information
External Reference
sirolimus [Guide to Pharmacology:6031]
Participates
as an input of
FKBP1A binds sirolimus (Saccharomyces cerevisiae)
FKBP1A binds sirolimus (Schizosaccharomyces pombe)
FKBP1A binds sirolimus (Caenorhabditis elegans)
FKBP1A binds sirolimus (Drosophila melanogaster)
FKBP1A binds sirolimus (Gallus gallus)
FKBP1A binds sirolimus (Xenopus tropicalis)
FKBP1A binds sirolimus (Danio rerio)
FKBP1A binds sirolimus (Sus scrofa)
FKBP1A binds sirolimus (Bos taurus)
FKBP1A binds sirolimus (Canis familiaris)
FKBP1A binds sirolimus (Rattus norvegicus)
FKBP1A binds sirolimus (Mus musculus)
FKBP1A binds sirolimus (Homo sapiens)
FKBP1A binds sirolimus (Dictyostelium discoideum)
as a component of
FKBP1A:sirolimus [cytosol] (Sus scrofa)
FKBP1A:sirolimus [cytosol] (Danio rerio)
FKBP1A:sirolimus [cytosol] (Mus musculus)
FKBP1A:sirolimus [cytosol] (Saccharomyces cerevisiae)
FKBP1A:sirolimus [cytosol] (Drosophila melanogaster)
FKBP1A:sirolimus [cytosol] (Rattus norvegicus)
FKBP1A:sirolimus [cytosol] (Canis familiaris)
FKBP1A:sirolimus [cytosol] (Caenorhabditis elegans)
FKBP1A:sirolimus [cytosol] (Xenopus tropicalis)
FKBP1A:sirolimus [cytosol] (Gallus gallus)
FKBP1A:sirolimus [cytosol] (Schizosaccharomyces pombe)
FKBP1A:sirolimus [cytosol] (Bos taurus)
FKBP1A:sirolimus [cytosol] (Homo sapiens)
FKBP1A:sirolimus [cytosol] (Dictyostelium discoideum)
Disease
Name
Identifier
Synonyms
autoimmune hypersensitivity disease
DOID:417
autoimmune disease, hypersensitivity reaction type II disease
Cross References
Pharos - Ligands
KG4MHLNXP966
PubChem Compound
178102653
PharmacoDB
PDBC00109
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