Reactome | TDM,alpha-mannan [plasma membrane]

TDM,alpha-mannan [plasma membrane]

Stable Identifier

R-ALL-9038391

Type

Set [DefinedSet]

Compartment

plasma membrane

Locations in the PathwayBrowser

for Species:

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Immune System (Danio rerio)

- Innate Immune System (Danio rerio)
  - C-type lectin receptors (CLRs) (Danio rerio)
    - Dectin-2 family (Danio rerio)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK autophosphorylates (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK binds to p-Y65,Y76-FCER1G (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Danio rerio)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Danio rerio)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Danio rerio)
        
        TDM,alpha-mannan [plasma membrane]

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - Dectin-2 family (Homo sapiens)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
      - PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
      - PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK autophosphorylates (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
        
        TDM,alpha-mannan [plasma membrane]

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - C-type lectin receptors (CLRs) (Mus musculus)
    - Dectin-2 family (Mus musculus)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
      - PLCG2 translocates from cytosol to plasma membrane (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK autophosphorylates (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK binds to p-Y65,Y76-FCER1G (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        TDM,alpha-mannan [plasma membrane]

Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - C-type lectin receptors (CLRs) (Rattus norvegicus)
    - Dectin-2 family (Rattus norvegicus)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
      - PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK autophosphorylates (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        TDM,alpha-mannan [plasma membrane]

Participants

members

Participates

as an input of

as a component of

Disease

Name	Identifier	Synonyms
bacterial infectious disease	DOID:104
fungal infectious disease	DOID:1564	mycoses, mycosis

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