CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate

Stable Identifier
R-HSA-5621354
Type
Reaction [binding]
Species
Homo sapiens
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CLEC4E (also called Mincle or CLECSF9) is a C-type lectin receptor (CLR) expressed in activated macrophages and dendritic cells (DCs) in response to several inflammatory stimuli, including LPS, TNF, IL6, IFN-gamma and cellular stresses (Matsumoto et al. 1999). Like the other activating receptors in the Dectin-2 family, CLEC4E is coupled with the FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to transduce intracellular signalling (Yamasaki et al. 2008). CLEC4E possesses a typical carbohydrate recognition domain (CRD) containing an EPN (Glu-Pro-Asn) motif which is capable of recognising several types of carbohydrates, particularly those containing alpha-mannose. CLEC4E can recognise fungal (Candida albicans and Malassezia), mycobacterial (trehalose-6,6?-dimycolate (TDM)) and necrotic cell ligands implicating this receptor in anti-microbial immunity and homeostasis (Schoenen et al. 2010, Yamasaki et al. 2009, Graham & Brown. 2009).

Literature References
PubMed ID Title Journal Year
18490740 The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

Wells, CA, Salvage-Jones, JA, Li, X, Hitchens, K, Butcher, S, Murray, RZ, Beckhouse, AG, Lo, YL, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, DA, Stow, J, Blanchard, H, Ashman, RB

J. Immunol. 2008
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