Reactome | CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate

CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate

Stable Identifier

R-HSA-5621354

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate

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CLEC4E (also called Mincle or CLECSF9) is a C-type lectin receptor (CLR) expressed in activated macrophages and dendritic cells (DCs) in response to several inflammatory stimuli, including LPS, TNF, IL6, IFN-gamma and cellular stresses (Matsumoto et al. 1999). Like the other activating receptors in the Dectin-2 family, CLEC4E is coupled with the FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to transduce intracellular signalling (Yamasaki et al. 2008). CLEC4E possesses a typical carbohydrate recognition domain (CRD) containing an EPN (Glu-Pro-Asn) motif which is capable of recognising several types of carbohydrates, particularly those containing alpha-mannose. CLEC4E can recognise fungal (Candida albicans and Malassezia), mycobacterial (trehalose-6,6?-dimycolate (TDM)) and necrotic cell ligands implicating this receptor in anti-microbial immunity and homeostasis (Schoenen et al. 2010, Yamasaki et al. 2009, Graham & Brown. 2009).

Literature References

PubMed ID	Title	Journal	Year
18490740	The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans Blanchard, H, Sobieszczuk, P, Li, X, Hitchens, K, Lebus, D, Stow, J, Stewart, L, Schroder, K, Ashman, RB, Ma, B, Hume, DA, Lo, YL, Salvage-Jones, JA, Cobbold, C, Orr, S, Manzanero, S, Wells, CA, Beckhouse, AG, Murray, RZ, Butcher, S	J. Immunol.	2008