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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
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Analysis Gene Expression
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Tissue Distribution
Diseases
Cytomics
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Go!
NCA [extracellular region]
Stable Identifier
R-ALL-8869604
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
nicotinate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Nicotinate metabolism (Bos taurus)
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Bos taurus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
HCAR2 binds HCAR2 ligands (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Bos taurus)
HCAR2 binds HCAR2 ligands (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Bos taurus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Bos taurus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
SLC-mediated transport of organic anions (Bos taurus)
Organic anion transport by SLC5/17/25 transporters (Bos taurus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Bos taurus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Caenorhabditis elegans)
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Nicotinate metabolism (Caenorhabditis elegans)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Caenorhabditis elegans)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
SLC-mediated transport of organic anions (Caenorhabditis elegans)
Organic anion transport by SLC5/17/25 transporters (Caenorhabditis elegans)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Caenorhabditis elegans)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Nicotinate metabolism (Canis familiaris)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Canis familiaris)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Canis familiaris)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
HCAR2 binds HCAR2 ligands (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Canis familiaris)
HCAR2 binds HCAR2 ligands (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Canis familiaris)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Canis familiaris)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
SLC-mediated transport of organic anions (Canis familiaris)
Organic anion transport by SLC5/17/25 transporters (Canis familiaris)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Canis familiaris)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Danio rerio)
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Danio rerio)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Danio rerio)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HCAR2:HCAR2 ligands [plasma membrane] (Danio rerio)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Danio rerio)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HCAR2:HCAR2 ligands [plasma membrane] (Danio rerio)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Danio rerio)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
HCAR2 binds HCAR2 ligands (Danio rerio)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Danio rerio)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Danio rerio)
HCAR2 binds HCAR2 ligands (Danio rerio)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Danio rerio)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Danio rerio)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Danio rerio)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
SLC-mediated transport of organic anions (Danio rerio)
Organic anion transport by SLC5/17/25 transporters (Danio rerio)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Danio rerio)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Nicotinate metabolism (Drosophila melanogaster)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Drosophila melanogaster)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Drosophila melanogaster)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
SLC-mediated transport of organic anions (Drosophila melanogaster)
Organic anion transport by SLC5/17/25 transporters (Drosophila melanogaster)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Drosophila melanogaster)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Nicotinate metabolism (Gallus gallus)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Gallus gallus)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Gallus gallus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
SLC-mediated transport of organic anions (Gallus gallus)
Organic anion transport by SLC5/17/25 transporters (Gallus gallus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Gallus gallus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Homo sapiens)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Homo sapiens)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
HCAR2 binds HCAR2 ligands (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Homo sapiens)
HCAR2 binds HCAR2 ligands (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
SLC-mediated transport of organic anions (Homo sapiens)
Organic anion transport by SLC5/17/25 transporters (Homo sapiens)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Homo sapiens)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Mus musculus)
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Nicotinate metabolism (Mus musculus)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Mus musculus)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Mus musculus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
HCAR2 binds HCAR2 ligands (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Mus musculus)
HCAR2 binds HCAR2 ligands (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Mus musculus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Mus musculus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
SLC-mediated transport of organic anions (Mus musculus)
Organic anion transport by SLC5/17/25 transporters (Mus musculus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Mus musculus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Nicotinate metabolism (Rattus norvegicus)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Rattus norvegicus)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Rattus norvegicus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
HCAR2:HCAR2 ligands [plasma membrane] (Rattus norvegicus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Rattus norvegicus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
HCAR2:HCAR2 ligands [plasma membrane] (Rattus norvegicus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Rattus norvegicus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
HCAR2 binds HCAR2 ligands (Rattus norvegicus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Rattus norvegicus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Rattus norvegicus)
HCAR2 binds HCAR2 ligands (Rattus norvegicus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Rattus norvegicus)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Rattus norvegicus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Rattus norvegicus)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
SLC-mediated transport of organic anions (Rattus norvegicus)
Organic anion transport by SLC5/17/25 transporters (Rattus norvegicus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Rattus norvegicus)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Nicotinate metabolism (Sus scrofa)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Sus scrofa)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Sus scrofa)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
HCAR2:HCAR2 ligands [plasma membrane] (Sus scrofa)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Sus scrofa)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
HCAR2:HCAR2 ligands [plasma membrane] (Sus scrofa)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Sus scrofa)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
HCAR2 binds HCAR2 ligands (Sus scrofa)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Sus scrofa)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
Hydroxycarboxylic acid-binding receptors (Sus scrofa)
HCAR2 binds HCAR2 ligands (Sus scrofa)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR2:HCAR2 ligands [plasma membrane] (Sus scrofa)
HCAR2 ligands [extracellular region]
NCA [extracellular region]
HCAR3 binds HCAR3 ligands (Sus scrofa)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
HCAR3:HCAR3 ligands [plasma membrane] (Sus scrofa)
HCAR3 ligands [extracellular region]
NCA [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
SLC-mediated transport of organic anions (Sus scrofa)
Organic anion transport by SLC5/17/25 transporters (Sus scrofa)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Sus scrofa)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Sus scrofa)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Nicotinate metabolism (Xenopus tropicalis)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Xenopus tropicalis)
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Xenopus tropicalis)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
SLC-mediated transport of organic anions (Xenopus tropicalis)
Organic anion transport by SLC5/17/25 transporters (Xenopus tropicalis)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)
LACT, PYR, NCA [extracellular region]
NCA [extracellular region]
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (Xenopus tropicalis)
monocarboxylates transported by SLC5A8 [extracellular region]
NCA [extracellular region]
External Reference Information
External Reference
nicotinate [ChEBI:32544]
Participates
as an input of
SLC22A13 exchanges extracellular NCA for cytosolic urate (Caenorhabditis elegans)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Drosophila melanogaster)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Gallus gallus)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Xenopus tropicalis)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Danio rerio)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Sus scrofa)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Canis familiaris)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Mus musculus)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Homo sapiens)
SLC22A13 exchanges extracellular NCA for cytosolic urate (Rattus norvegicus)
as a member of
LACT, PYR, NCA [extracellular region]
monocarboxylates transported by SLC5A8 [extracellular region]
HCAR3 ligands [extracellular region]
HCAR2 ligands [extracellular region]
Other forms of this molecule
NCA [cytosol]
Cross References
ZINC
ZINC000000001795
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