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mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Stable Identifier
R-ALL-450425
Type
OtherEntity
Compartment
cytosol
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Drosophila melanogaster
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Metabolism of RNA (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
HuR (ELAVL1) binds and stabilizes mRNA (Bos taurus)
HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)
HuR:mRNA Complex [cytosol] (Bos taurus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Bos taurus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Metabolism of RNA (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
HuR (ELAVL1) binds and stabilizes mRNA (Canis familiaris)
HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)
HuR:mRNA Complex [cytosol] (Canis familiaris)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Canis familiaris)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Metabolism of RNA (Drosophila melanogaster)
Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
HuR (ELAVL1) binds and stabilizes mRNA (Drosophila melanogaster)
HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)
HuR:mRNA Complex [cytosol] (Drosophila melanogaster)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Drosophila melanogaster)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)
HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)
HuR:mRNA Complex [cytosol] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Homo sapiens)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
HuR (ELAVL1) binds and stabilizes mRNA (Mus musculus)
HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)
HuR:mRNA Complex [cytosol] (Mus musculus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Mus musculus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Metabolism of RNA (Rattus norvegicus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Rattus norvegicus)
HuR (ELAVL1) binds and stabilizes mRNA (Rattus norvegicus)
HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)
HuR:mRNA Complex [cytosol] (Rattus norvegicus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Rattus norvegicus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
Metabolism of RNA (Sus scrofa)
Regulation of mRNA stability by proteins that bind AU-rich elements (Sus scrofa)
HuR (ELAVL1) binds and stabilizes mRNA (Sus scrofa)
HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)
HuR:mRNA Complex [cytosol] (Sus scrofa)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Sus scrofa)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318 [cytosol]
General
Phosphorylated HuR (phosphoserine158 and phosphoserine318) binds AU-rich elements in the Cyclooxygenase-2 (COX-2, PTGS2) mRNA.
Literature References
PubMed ID
Title
Journal
Year
17392515
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
Pfeilschifter, J
,
Müller, R
,
Doller, A
,
Huwiler, A
,
Eberhardt, W
,
Radeke, HH
Mol Biol Cell
2007
Participates
as a component of
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Rattus norvegicus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Mus musculus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Bos taurus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Canis familiaris)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Sus scrofa)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Drosophila melanogaster)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [cytosol] (Homo sapiens)
Cross References
ChEBI
33697
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