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What is Reactome ?
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CIM [extracellular region]
Stable Identifier
R-ALL-446609
Type
ChemicalDrug
Compartment
extracellular region
Synonyms
cimetidine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Amine ligand-binding receptors (Bos taurus)
Histamine receptors (Bos taurus)
HRH2 binds HRH2 antagonists (Bos taurus)
HRH2:HRH2 antagonists [plasma membrane] (Bos taurus)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
MATEs mediate extrusion of xenobiotics (Bos taurus)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Bos taurus)
Organic anion transport (Bos taurus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Bos taurus)
OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR ligand binding (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Amine ligand-binding receptors (Caenorhabditis elegans)
Histamine receptors (Caenorhabditis elegans)
HRH2 binds HRH2 antagonists (Caenorhabditis elegans)
HRH2:HRH2 antagonists [plasma membrane] (Caenorhabditis elegans)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic anion transport (Caenorhabditis elegans)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Caenorhabditis elegans)
OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Amine ligand-binding receptors (Canis familiaris)
Histamine receptors (Canis familiaris)
HRH2 binds HRH2 antagonists (Canis familiaris)
HRH2:HRH2 antagonists [plasma membrane] (Canis familiaris)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
MATEs mediate extrusion of xenobiotics (Canis familiaris)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic anion transport (Canis familiaris)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Canis familiaris)
OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Amine ligand-binding receptors (Danio rerio)
Histamine receptors (Danio rerio)
HRH2 binds HRH2 antagonists (Danio rerio)
HRH2:HRH2 antagonists [plasma membrane] (Danio rerio)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
MATEs mediate extrusion of xenobiotics (Danio rerio)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Danio rerio)
Organic anion transport (Danio rerio)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Danio rerio)
OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)
MATE substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR ligand binding (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Amine ligand-binding receptors (Drosophila melanogaster)
Histamine receptors (Drosophila melanogaster)
HRH2 binds HRH2 antagonists (Drosophila melanogaster)
HRH2:HRH2 antagonists [plasma membrane] (Drosophila melanogaster)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic anion transport (Drosophila melanogaster)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Drosophila melanogaster)
OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Amine ligand-binding receptors (Gallus gallus)
Histamine receptors (Gallus gallus)
HRH2 binds HRH2 antagonists (Gallus gallus)
HRH2:HRH2 antagonists [plasma membrane] (Gallus gallus)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
MATEs mediate extrusion of xenobiotics (Gallus gallus)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic anion transport (Gallus gallus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Gallus gallus)
OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH2 binds HRH2 antagonists (Homo sapiens)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2:HRH2 antagonists [plasma membrane] (Homo sapiens)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
MATEs mediate extrusion of xenobiotics (Homo sapiens)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic anion transport (Homo sapiens)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Amine ligand-binding receptors (Mus musculus)
Histamine receptors (Mus musculus)
HRH2 binds HRH2 antagonists (Mus musculus)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2:HRH2 antagonists [plasma membrane] (Mus musculus)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
MATEs mediate extrusion of xenobiotics (Mus musculus)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Mus musculus)
Organic anion transport (Mus musculus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Mus musculus)
OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)
MATE substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Amine ligand-binding receptors (Rattus norvegicus)
Histamine receptors (Rattus norvegicus)
HRH2 binds HRH2 antagonists (Rattus norvegicus)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2:HRH2 antagonists [plasma membrane] (Rattus norvegicus)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
MATEs mediate extrusion of xenobiotics (Rattus norvegicus)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic anion transport (Rattus norvegicus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Rattus norvegicus)
OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)
MATE substrates [extracellular region]
CIM [extracellular region]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)
MATE substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Amine ligand-binding receptors (Sus scrofa)
Histamine receptors (Sus scrofa)
HRH2 binds HRH2 antagonists (Sus scrofa)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2:HRH2 antagonists [plasma membrane] (Sus scrofa)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
MATEs mediate extrusion of xenobiotics (Sus scrofa)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic anion transport (Sus scrofa)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Sus scrofa)
OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)
OCT2 substrates [extracellular region]
CIM [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR ligand binding (Xenopus tropicalis)
Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
Amine ligand-binding receptors (Xenopus tropicalis)
Histamine receptors (Xenopus tropicalis)
HRH2 binds HRH2 antagonists (Xenopus tropicalis)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
HRH2:HRH2 antagonists [plasma membrane] (Xenopus tropicalis)
HRH2 antagonists [extracellular region] (Homo sapiens)
CIM [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)
MATE substrates [extracellular region]
CIM [extracellular region]
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Organic anion transport (Xenopus tropicalis)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)
OAT1-3 substrates [extracellular region]
CIM [extracellular region]
Organic cation transport (Xenopus tropicalis)
OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [extracellular region]
CIM [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [extracellular region]
CIM [extracellular region]
External Reference Information
External Reference
cimetidine [Guide to Pharmacology:1231]
Participates
as a member of
MATE substrates [extracellular region]
OCT2 substrates [extracellular region]
OAT1-3 substrates [extracellular region]
HRH2 antagonists [extracellular region] (Homo sapiens)
Other forms of this molecule
CIM [cytosol]
Disease
Name
Identifier
Synonyms
gastroesophageal reflux disease
DOID:8534
Gastroesophageal reflux, Gastresophageal reflux, GERD, Acid reflux, GERD - Gastro-esophageal reflux disease, Gastroesophageal reflux disease, Gastro-esophageal reflux
gastric ulcer
DOID:10808
acute gastric ulcer with hemorrhage and perforation, with obstruction, chronic gastric ulcer without hemorrhage AND without perforation, chronic gastric ulcer without hemorrhage AND without perforation but with obstruction, acute gastric ulcer with hemorrhage AND obstruction, acute gastric ulcer with hemorrhage and obstruction, acute gastric ulcer with hemorrhage, with perforation AND with obstruction, acute gastric ulcer with perforation, with obstruction, acute gastric ulcer with hemorrhage and perforation, acute gastric ulcer with hemorrhage AND perforation, acute gastric ulcer with hemorrhage, with obstruction, acute gastric ulcer without hemorrhage, without perforation AND without obstruction, acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction, acute gastric ulcer without hemorrhage and without perforation, acute gastric ulcer with hemorrhage AND with perforation but without obstruction, bleeding acute gastric ulcer, acute gastric ulcer with perforation AND obstruction, acute gastric ulcer with perforation, acute gastric ulcer with haemorrhage and perforation, chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction, acute gastric ulcer with hemorrhage and perforation, without mention of obstruction
Cross References
COMPOUND
C06952
ChEBI
3699
Pharos - Ligands
2HM79A95BD25
PharmacoDB
PDBC00779
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