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Go!
CIM [cytosol]
Stable Identifier
R-ALL-446602
Type
ChemicalDrug
Compartment
cytosol
Synonyms
cimetidine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
MATEs mediate extrusion of xenobiotics (Bos taurus)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Bos taurus)
Organic anion transport (Bos taurus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Bos taurus)
OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic anion transport (Caenorhabditis elegans)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Caenorhabditis elegans)
OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
MATEs mediate extrusion of xenobiotics (Canis familiaris)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic anion transport (Canis familiaris)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Canis familiaris)
OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
MATEs mediate extrusion of xenobiotics (Danio rerio)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Danio rerio)
Organic anion transport (Danio rerio)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Danio rerio)
OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)
MATE substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic anion transport (Drosophila melanogaster)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Drosophila melanogaster)
OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
MATEs mediate extrusion of xenobiotics (Gallus gallus)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic anion transport (Gallus gallus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Gallus gallus)
OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
MATEs mediate extrusion of xenobiotics (Homo sapiens)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic anion transport (Homo sapiens)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
MATEs mediate extrusion of xenobiotics (Mus musculus)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Mus musculus)
Organic anion transport (Mus musculus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Mus musculus)
OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)
MATE substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
MATEs mediate extrusion of xenobiotics (Rattus norvegicus)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic anion transport (Rattus norvegicus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Rattus norvegicus)
OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)
MATE substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)
MATE substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
MATEs mediate extrusion of xenobiotics (Sus scrofa)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic anion transport (Sus scrofa)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Sus scrofa)
OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)
OCT2 substrates [cytosol]
CIM [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)
MATE substrates [cytosol]
CIM [cytosol]
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Organic anion transport (Xenopus tropicalis)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)
OAT1-3 substrates [cytosol]
CIM [cytosol]
Organic cation transport (Xenopus tropicalis)
OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [cytosol]
CIM [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [cytosol]
CIM [cytosol]
External Reference Information
External Reference
cimetidine [Guide to Pharmacology:1231]
Participates
as a member of
MATE substrates [cytosol]
OCT2 substrates [cytosol]
OAT1-3 substrates [cytosol]
Other forms of this molecule
CIM [extracellular region]
Disease
Name
Identifier
Synonyms
gastroesophageal reflux disease
DOID:8534
Gastroesophageal reflux, Gastresophageal reflux, GERD, Acid reflux, GERD - Gastro-esophageal reflux disease, Gastroesophageal reflux disease, Gastro-esophageal reflux
gastric ulcer
DOID:10808
acute gastric ulcer with hemorrhage and perforation, with obstruction, chronic gastric ulcer without hemorrhage AND without perforation, chronic gastric ulcer without hemorrhage AND without perforation but with obstruction, acute gastric ulcer with hemorrhage AND obstruction, acute gastric ulcer with hemorrhage and obstruction, acute gastric ulcer with hemorrhage, with perforation AND with obstruction, acute gastric ulcer with perforation, with obstruction, acute gastric ulcer with hemorrhage and perforation, acute gastric ulcer with hemorrhage AND perforation, acute gastric ulcer with hemorrhage, with obstruction, acute gastric ulcer without hemorrhage, without perforation AND without obstruction, acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction, acute gastric ulcer without hemorrhage and without perforation, acute gastric ulcer with hemorrhage AND with perforation but without obstruction, bleeding acute gastric ulcer, acute gastric ulcer with perforation AND obstruction, acute gastric ulcer with perforation, acute gastric ulcer with haemorrhage and perforation, chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction, acute gastric ulcer with hemorrhage and perforation, without mention of obstruction
Cross References
COMPOUND
C06952
ChEBI
3699
Pharos - Ligands
2HM79A95BD25
PharmacoDB
PDBC00779
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