Reactome | aliskiren [extracellular region]

aliskiren [extracellular region]

Stable Identifier

R-ALL-2022362

Type

ChemicalDrug

Compartment

extracellular region

Locations in the PathwayBrowser

for Species:

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External Reference Information

External Reference

aliskiren [Guide to Pharmacology:4812]

This entity regulates

Negatively

Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Xenopus tropicalis)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Danio rerio)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Bos taurus)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Rattus norvegicus)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Homo sapiens)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Xenopus tropicalis)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Danio rerio)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Bos taurus)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Rattus norvegicus)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Xenopus tropicalis)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Danio rerio)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Bos taurus)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Rattus norvegicus)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Canis familiaris)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Mus musculus)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Canis familiaris)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Mus musculus)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Homo sapiens)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Canis familiaris)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Mus musculus)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Drosophila melanogaster)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Gallus gallus)
Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Sus scrofa)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Drosophila melanogaster)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Gallus gallus)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (Sus scrofa)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Drosophila melanogaster)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Gallus gallus)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Sus scrofa)
Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) (Homo sapiens)

Disease

Name	Identifier	Synonyms
hypertension	DOID:10763	High blood pressure (& [essential hypertension]), HTN, hypertensive disease, hyperpiesia, vascular hypertensive disorder

Cross References

Mondo

0005044

ChEBI

601027

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